Phenotypes associated with this allele

• Allele Symbol: Siah2^tm1Ddlb
• Allele Name: targeted mutation 1, David D L Bowtell
• Allele ID: MGI:2683932
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae	MGI:3761116
hm2	Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae * C57BL/6J	MGI:2684006
cx3	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S1/Sv * 129S4/SvJae	MGI:3761117
cx4	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^+	involves: 129S4/SvJae * C57BL/6J	MGI:2684007
cx5	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae * C57BL/6J	MGI:2684008

Genotype
MGI:3761116

hm1

• Allelic Composition: Siah2^tm1Ddlb/Siah2^tm1Ddlb
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:126183 )

N • mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation

Genotype
MGI:2684006

hm2

• Allelic Composition: Siah2^tm1Ddlb/Siah2^tm1Ddlb
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

skeleton

abnormal bone marrow morphology ( J:86820 )

• expanded myeloid progenitor compartement in bone marrow by semisolid colony forming cell assay

• expanded potential for osteoclast formation in vitro but not in vivo

Genotype
MGI:3761117

cx3

• Allelic Composition: Siah1a^tm1Ddlb/Siah1a^tm1Ddlb; Siah2^tm1Ddlb/Siah2^tm1Ddlb
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae

cellular

cellular phenotype ( J:126183 )

N • mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation

Genotype
MGI:2684007

cx4

• Allelic Composition: Siah1a^tm1Ddlb/Siah1a^tm1Ddlb; Siah2^tm1Ddlb/Siah2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:86820 )

• all are dead by day 5

perinatal lethality, incomplete penetrance ( J:86820 )

• most pups die within the first day; all are dead by day 5

Genotype
MGI:2684008

cx5

• Allelic Composition: Siah1a^tm1Ddlb/Siah1a^tm1Ddlb; Siah2^tm1Ddlb/Siah2^tm1Ddlb
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:86820 )

• pups die within hours of birth; cause of death unknown

prenatal lethality, incomplete penetrance ( J:86820 )

• homozygotes are born at below expected frequency