cellular
N |
• mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation
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Allele Symbol Allele Name Allele ID |
Siah2tm1Ddlb targeted mutation 1, David D L Bowtell MGI:2683932 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• expanded myeloid progenitor compartement in bone marrow by semisolid colony forming cell assay
• expanded potential for osteoclast formation in vitro but not in vivo
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• all are dead by day 5
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• most pups die within the first day; all are dead by day 5
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• pups die within hours of birth; cause of death unknown
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• homozygotes are born at below expected frequency
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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