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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcl1tm2Sjk
targeted mutation 2, Stanley J Korsmeyer
MGI:2684150
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Mcl1tm2Sjk/Mcl1tm3Sjk 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:2684157
cn2
 		Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Mx1-cre)1Cgn/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:2684174
cn3
 		Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Lck-cre)1Cwi/0 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:2684156


Genotype
MGI:2684157
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Mcl1tm2Sjk mutation (1 available); any Mcl1 mutation (35 available)
Mcl1tm3Sjk mutation (1 available); any Mcl1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage
arrested B cell differentiation ( J:86906 )
• arrested at pro-B cell stage
decreased B cell number ( J:86906 )
• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination

immune system
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage
arrested B cell differentiation ( J:86906 )
• arrested at pro-B cell stage
decreased B cell number ( J:86906 )
• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination

cellular
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage




Genotype
MGI:2684174
cn2
Allelic
Composition		 Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm2Sjk mutation (1 available); any Mcl1 mutation (35 available)
Mcl1tm3Sjk mutation (1 available); any Mcl1 mutation (35 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:86906 )
• peripheral B cells are not maintained
decreased T cell number ( J:86906 )
• peripheral T cells are not maintained

immune system
decreased B cell number ( J:86906 )
• peripheral B cells are not maintained
decreased T cell number ( J:86906 )
• peripheral T cells are not maintained




Genotype
MGI:2684156
cn3
Allelic
Composition		 Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm2Sjk mutation (1 available); any Mcl1 mutation (35 available)
Mcl1tm3Sjk mutation (1 available); any Mcl1 mutation (35 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell apoptosis ( J:86906 )
• increased apoptosis at double negative T cell stage
arrested T cell differentiation ( J:86906 )
• block at the double-negative stage between DN2 and DN3
decreased T cell number ( J:86906 )
• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
decreased thymocyte number ( J:86906 )
• reduction of the total number of thymocytes
decreased double-negative T cell number ( J:86906 )
• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets

immune system
increased T cell apoptosis ( J:86906 )
• increased apoptosis at double negative T cell stage
arrested T cell differentiation ( J:86906 )
• block at the double-negative stage between DN2 and DN3
decreased T cell number ( J:86906 )
• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
decreased thymocyte number ( J:86906 )
• reduction of the total number of thymocytes
decreased double-negative T cell number ( J:86906 )
• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets

cellular
increased T cell apoptosis ( J:86906 )
• increased apoptosis at double negative T cell stage

endocrine/exocrine glands
decreased thymocyte number ( J:86906 )
• reduction of the total number of thymocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory