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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Med1tm1Mpk
targeted mutation 1, Malcom G Parker
MGI:2684189
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Med1tm1Mpk/Med1tm1Mpk involves: 129P2/OlaHsd * C57BL/6J MGI:2684221


Genotype
MGI:2684221
hm1
Allelic
Composition
Med1tm1Mpk/Med1tm1Mpk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med1tm1Mpk mutation (0 available); any Med1 mutation (83 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all were necrotic by E14.0
• death due to hepatic hemorrhagic necrosis and poor myocardial development

cardiovascular system
• by E13.5 heart is very degenerate
• at the apex by E12.5
• some peripheral compaction

hematopoietic system
• by E11.25 excessive nucleated erythrocytes in dilated sinusoids of liver

limbs/digits/tail
• limb development a day behind by E13.5

muscle

vision/eye
• eye development delayed about a day by E13.5

embryo
• by E13.5 severe growth retardation could be detected

growth/size/body
• by E13.5 severe growth retardation could be detected





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory