mortality/aging
• all were necrotic by E14.0
• death due to hepatic hemorrhagic necrosis and poor myocardial development
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cardiovascular system
• by E13.5 heart is very degenerate
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• by E12.5
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• at the apex by E12.5
• some peripheral compaction
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hematopoietic system
• by E11.25 excessive nucleated erythrocytes in dilated sinusoids of liver
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limbs/digits/tail
• limb development a day behind by E13.5
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muscle
• by E12.5
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vision/eye
• eye development delayed about a day by E13.5
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embryo
• by E13.5 severe growth retardation could be detected
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growth/size/body
• by E13.5 severe growth retardation could be detected
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