Phenotypes associated with this allele

• Allele Symbol: Med1^tm1.1Mpk
• Allele Name: targeted mutation 1.1, Malcom G Parker
• Allele ID: MGI:2684191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Med1^tm1.1Mpk/Med1^tm1.1Mpk	involves: 129P2/OlaHsd * C57BL/6J	MGI:2684225

Genotype
MGI:2684225

hm1

• Allelic Composition: Med1^tm1.1Mpk/Med1^tm1.1Mpk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86857 )

• embryos die before E12.0

• death at E11.5 primarily due to placental insufficiency

• after tetraploid rescue, death at E13.5 from hepatic hemorrhagic necrosis and poor myocardial development

embryo

impaired placental function ( J:86857 )

• placental insufficiency at E11.5

cardiovascular system

abnormal heart morphology ( J:86857 )

• endocardium eventually becomes detatched from myocardium

• after tetraploid rescue, hearts become very degenerate and congested by E13.5

ventricular hypoplasia ( J:86857 )

• at E9.5

trabecula carnea hypoplasia ( J:86857 )

• impaired development at E9.5

thin ventricular wall ( J:86857 )

• by E10.5

• severe non compaction of myocardium

hematopoietic system

absent megakaryocytes ( J:86857 )

• mature megakaryocytes missing in embryos

increased nucleated erythrocyte cell number ( J:86857 )

• by E11.5, excessive nucleated erythrocytes in dilated sinusoids of liver

limbs/digits/tail

abnormal limb morphology ( J:86857 )

• only in embryos resulting from tetraploid rescue

• limb development a day behind by E13.5

muscle

trabecula carnea hypoplasia ( J:86857 )

• impaired development at E9.5

vision/eye

abnormal eye development ( J:86857 )

• only in embryos rescued by tetraploid rescue

• eye development delayed about a day by E13.5