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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mbd4tm2Abc
targeted mutation 2, Alfonso Bellacosa
MGI:2684310
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mbd4tm2Abc/Mbd4tm2Abc involves: 129/Sv * 129X1/SvJ * C57BL/6 MGI:3719423


Genotype
MGI:3719423
hm1
Allelic
Composition
Mbd4tm2Abc/Mbd4tm2Abc
Genetic
Background
involves: 129/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd4tm2Abc mutation (0 available); any Mbd4 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint
• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) exhibit a decrease in apoptosis
• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil
• however, MEFs are susceptible to apoptosis induced by an amphotropic avian sarcoma virus-based vector

homeostasis/metabolism
• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint and exhibit a decrease in apoptosis
• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory