cellular
• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint
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• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) exhibit a decrease in apoptosis
• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil
• however, MEFs are susceptible to apoptosis induced by an amphotropic avian sarcoma virus-based vector
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homeostasis/metabolism
• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint and exhibit a decrease in apoptosis
• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil
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