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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pdx1-cre/Esr1*)35.10Dam
transgene insertion 35.10, Douglas A Melton
MGI:2684321
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0 		involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA MGI:3821752
cn2
 		Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:3821753
cn3
 		Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4436916
cn4
 		Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre/Esr1*)35.10Dam/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4836238
cn5
 		Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3821738


Genotype
MGI:3821752
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• mice treated with tamoxifen staring at E10.5 exhibit pancreatic intraepithelial neoplasia (PanIN) that overtakes nearly all of the organ
• mice not treated with tamoxifen develop focal PanIN that are more numerous than in Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice
• acinar-ductal metaplasia precedes PanIN

endocrine/exocrine glands
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• mice treated with tamoxifen staring at E10.5 exhibit pancreatic intraepithelial neoplasia (PanIN) that overtakes nearly all of the organ
• mice not treated with tamoxifen develop focal PanIN that are more numerous than in Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice
• acinar-ductal metaplasia precedes PanIN




Genotype
MGI:3821753
cn2
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• acinar-ductal metaplasia precedes PanIN
• mice treated with tamoxifen staring at E10.5 exhibit focal pancreatic intraepithelial neoplasia
• mice not treated with tamoxifen develop focal PanIN that are not as numerous as in Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice

endocrine/exocrine glands
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• mice treated with tamoxifen staring at E10.5 exhibit focal pancreatic intraepithelial neoplasia
• mice not treated with tamoxifen develop focal PanIN that are not as numerous as in Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice
• acinar-ductal metaplasia precedes PanIN




Genotype
MGI:4436916
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreas development ( J:86975 )
• sequential injection of tamoxifen to pregnant females at E13.5 and E14.5 to activate cre recombinase results in a pancreatic tubular epithelium devoid of endocrine and exocrine markers, indicating impaired differentiation of progenitor cells
• however, when tamoxifen is injected into adults, mature endocrine are not perturbed




Genotype
MGI:4836238
cn4
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreatic islet hyperplasia ( J:102226 )
• mice injected with tamoxifen at 2-3 weeks of age, exhibit islet hyperplasia but no ductal abnormalities or increase in DBA staining




Genotype
MGI:3821738
cn5
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:142189 )
N
• mice treated with tamoxifen as adults do not develop pancreatic intraepithelial neoplasia




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11/12/2024
MGI 6.24 		The Jackson Laboratory