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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scgb1a1tm1Brst
targeted mutation 1, Barry R Stripp
MGI:2684333
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scgb1a1tm1Brst/Scgb1a1tm1Brst involves: 129P2/OlaHsd * 129P3/J MGI:2684341
hm2
 		Scgb1a1tm1Brst/Scgb1a1tm1Brst involves: 129P2/OlaHsd * 129P3/J * C57BL/6 MGI:2684342
hm3
 		Scgb1a1tm1Brst/Scgb1a1tm1Brst involves: 129P2/OlaHsd * Black Swiss MGI:2684340


Genotype
MGI:2684341
hm1
Allelic
Composition		 Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic
Background		 involves: 129P2/OlaHsd * 129P3/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1tm1Brst mutation (0 available); any Scgb1a1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal xenobiotic pharmacokinetics ( J:86895 )
• reduced accumulation of MeSO4-PCB in the lungs and kidneys

respiratory system
respiratory system phenotype ( J:86895 )
N
• no gross abnormalities observed
abnormal respiratory mucosa morphology ( J:86895 )
• airway cells were deficient in secretory granules by TEM examination
• 50% of cells with large membranous inclusions




Genotype
MGI:2684342
hm2
Allelic
Composition		 Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic
Background		 involves: 129P2/OlaHsd * 129P3/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1tm1Brst mutation (0 available); any Scgb1a1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal xenobiotic pharmacokinetics ( J:86895 )
• reduced accumulatation of MeSO4-PCB in the lungs and kidneys

respiratory system
respiratory system phenotype ( J:86895 )
N
• no gross abnormalities were observed
abnormal respiratory mucosa morphology ( J:86895 )
• airways were deficient in secretory granules by TEM examination
• 50% of cells with large membranous inclusions




Genotype
MGI:2684340
hm3
Allelic
Composition		 Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1tm1Brst mutation (0 available); any Scgb1a1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal xenobiotic pharmacokinetics ( J:86895 )
• reduced accumulation of MeSO4-PCB in the lungs and kidneys

respiratory system
respiratory system phenotype ( J:86895 )
N
• no gross abnormalities observed
abnormal respiratory mucosa morphology ( J:86895 )
• airway cells were deficient in secretory granules by TEM examination
• about 50% of cells with large membranous inclusions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory