Analysis Tools|
Allele Symbol Allele Name Allele ID |
Twist1Pas Pasteur MGI:2684436 |
| Summary |
2 genotypes |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 90% penetrant in (PDT/Pas x C57BL/6) F2 offspring.
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Saethre-Chotzen syndrome | DOID:14768 |
OMIM:101400 OMIM:180750 |
J:86815 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Polydactyly in the right hindlimb of Twist1Pas/Twist1+ mice
|
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly
|
|
• alterations in pattern development leads to the formation of one, but rarely two extra digits in the preaxial part of one of the hindlimbs, rarely both without left right preference
• penetrance varies with genetic background but is never complete
• genetic analysis reveals that this allele is sufficient to produce the polydactyly phenotype at a low frequency
|
|
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly
|
|
• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Saethre-Chotzen syndrome | DOID:14768 |
OMIM:101400 OMIM:180750 |
J:86815 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/17/2024 MGI 6.24 |
|
|
|
||
