Phenotypes associated with this allele

• Allele Symbol: Tal2^tm1Thr
• Allele Name: targeted mutation 1, Terence H Rabbitts
• Allele ID: MGI:2684532
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tal2^tm1Thr/Tal2^tm1Thr	involves: 129 * C57BL/6	MGI:3028632

Genotype
MGI:3028632

hm1

• Allelic Composition: Tal2^tm1Thr/Tal2^tm1Thr
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:65762 )

• many animals die between 21-24 days after birth; all die by 32 days

behavior/neurological

decreased locomotor activity ( J:65762 )

• periods of decreased activity were noted

convulsive seizures ( J:65762 )

• occasional convulsions noted

growth/size/body

postnatal growth retardation ( J:65762 )

• noticeable by 10-12 days of age

hematopoietic system

hematopoietic system phenotype ( J:65762 )

N • normal hematopoiesis; normal numbers of mature T cells, B cells, myeloid cells, and progenitors were noted

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:65762 )

N • normal blood chemistry; normal sodium, calcium, potassium, glucose, urea, creatinine levels

nervous system

convulsive seizures ( J:65762 )

• occasional convulsions noted

obstructive hydrocephaly ( J:65762 )

• hydrocephalus in lateral ventricles only, not in third or fourth ventricles probably due to obstruction of the foramen of Munro

dilated lateral ventricle ( J:65762 )

abnormal tectum morphology ( J:65762 )

• dysgenesis of midbrain tectum; first detectable at P2, obvious at P15

abnormal inferior colliculus morphology ( J:65762 )

• abnormally rounded and protruding

abnormal superior colliculus morphology ( J:65762 )

• layering in superior colliculus was disrupted

• superficial gray was hypoblastic and rudimentary

• optical layer was reduced in size and depth

decreased superior colliculus size ( J:65762 )

abnormal thalamus morphology ( J:65762 )

• distorted, compression of the fimbra fornix along the roof of the thalamus resulting in the obstruction of the foramen of Munro