Phenotypes associated with this allele

• Allele Symbol: Hcn4^tm1.1Jsr
• Allele Name: targeted mutation 1.1, Juliane Stieber
• Allele ID: MGI:2684538
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn4^tm1.1Jsr/Hcn4^tm1.1Jsr	involves: 129/Sv * C57BL/6	MGI:2684590

Genotype
MGI:2684590

hm1

• Allelic Composition: Hcn4^tm1.1Jsr/Hcn4^tm1.1Jsr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86988 )

• homozygous embryos died between E9.5 and E11.5

cardiovascular system

abnormal heart rate ( J:86988 )

• basal contraction rate of the embryonic heart is significantly reduced

• 75-90% reduction of cation current (I_f) at R9.0, E9.5, E10.5

• lack of pacemaker-like action potentials