Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^tm1(GFP)Cjs
• Allele Name: targeted mutation 1, Charles J Sherr
• Allele ID: MGI:2684603
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs	involves: 129S1/Sv * C57BL/6	MGI:2684614
cx2	Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Tgfb2^tm1Doe/Tgfb2^tm1Doe	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3848994
cx3	Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Tgfb2^tm1Doe/Tgfb2^+	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3848995

Genotype
MGI:2684614

hm1

• Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:87339 )

• untreated mice develop tumors

• depending on tumor size, type and location, many solid tumors exhibited vivid green fluorescence

• a 2: 1 frequency of sarcomas versus lymphomas was observed

increased gastrointestinal stromal tumor incidence ( J:87339 )

increased lymphoma incidence ( J:87339 )

• lymphomas comprised the remaining 33% of tumors

increased histiocytic sarcoma incidence ( J:87339 )

increased sarcoma incidence ( J:87339 )

• 65% of tumors were highly invasive sarcomas of various types including those with pleomorphic morphology, gastrointestinal stromal tumors, hemangiosarcomas, malignant peripheral nerve sheath tumors, histiocytic sarcomas

increased hemangiosarcoma incidence ( J:87339 )

increased incidence of tumors by ionizing radiation induction ( J:87339 )

• tumors arose more rapidly in animals that received a single 4 Gy dose of total body irradiation

digestive/alimentary system

increased gastrointestinal stromal tumor incidence ( J:87339 )

Genotype
MGI:3848994

cx2

• Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs; Tgfb2^tm1Doe/Tgfb2^tm1Doe
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

vision/eye

primary vitreous hyperplasia ( J:149526 )

• seen at E15.5

Genotype
MGI:3848995

cx3

• Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs; Tgfb2^tm1Doe/Tgfb2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

vision/eye

primary vitreous hyperplasia ( J:149526 )

• seen at E15.5