Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-cre)1Vln
• Allele Name: transgene insertion 1, Fred Van Leuven
• Allele ID: MGI:2684620
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ifngr1^tm1Dmer/Ifngr1^tm1Dmer Tg(Thy1-cre)1Vln/0	B6.Cg-Ifngr1^tm1Dmer Tg(Thy1-cre)1Vln	MGI:5552977
cn2	Panx1^tm1Vshe/Panx1^tm1Vshe Tg(Thy1-cre)1Vln/0	B6.Cg-Panx1^tm1Vshe Tg(Thy1-cre)1Vln	MGI:5488659
cn3	Dscam^tm1Pfu/Dscam^tm1Pfu Tg(Thy1-cre)1Vln/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5305037
cn4	Dctn1^tm2.1Cai/Dctn1^tm2.1Cai Tg(Thy1-cre)1Vln/?	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N	MGI:6201236
cn5	Psen1^tm1Vln/Psen1^tm1Vln Tg(Thy1-APPLon)2Vln/0 Tg(Thy1-cre)1Vln/0	involves: FVB/N	MGI:2684658
cn6	Psen1^tm1Vln/Psen1^tm1Vln Tg(Thy1-cre)1Vln/0	involves: FVB/N	MGI:2684657

Genotype
MGI:5552977

cn1

• Allelic Composition: Ifngr1^tm1Dmer/Ifngr1^tm1Dmer; Tg(Thy1-cre)1Vln/0
• Genetic Background: B6.Cg-Ifngr1^tm1Dmer Tg(Thy1-cre)1Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal response to infection ( J:202844 )

• mice fail to develop viral deja vu disease unlike wild-type mice

Genotype
MGI:5488659

cn2

• Allelic Composition: Panx1^tm1Vshe/Panx1^tm1Vshe; Tg(Thy1-cre)1Vln/0
• Genetic Background: B6.Cg-Panx1^tm1Vshe Tg(Thy1-cre)1Vln

nervous system

decreased neuron apoptosis ( J:196355 )

• following ischemia/reperfusion injury

increased retina ganglion cell number ( J:196355 )

• following ischemia/reperfusion injury

homeostasis/metabolism

abnormal response to injury ( J:196355 )

• following ischemia/reperfusion injury, retina exhibit reduced retinal ganglion cell (RGC) loss and increased RGC and neuronal survival with less apoptosis compared with wild-type mice

vision/eye

increased retina ganglion cell number ( J:196355 )

• following ischemia/reperfusion injury

cellular

decreased neuron apoptosis ( J:196355 )

• following ischemia/reperfusion injury

Genotype
MGI:5305037

cn3

• Allelic Composition: Dscam^tm1Pfu/Dscam^tm1Pfu; Tg(Thy1-cre)1Vln/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

vision/eye

abnormal retina ganglion cell morphology ( J:179393 )

• aggregation of recombined retinal ganglion cells

nervous system

abnormal retina ganglion cell morphology ( J:179393 )

• aggregation of recombined retinal ganglion cells

Genotype
MGI:6201236

cn4

• Allelic Composition: Dctn1^tm2.1Cai/Dctn1^tm2.1Cai; Tg(Thy1-cre)1Vln/?
• Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

behavior/neurological

limb grasping ( J:264431 )

• hindlimb clasping is observed in 18 month old mice

impaired coordination ( J:264431 )

• less time spent on rotating rods as compared to controls at 12 months of age

decreased vertical activity ( J:264431 )

• reduced rearing is observed by 18 months of age

cellular

increased susceptibility to neuronal excitotoxicity ( J:264431 )

• increased cell death in neurons after treatment with 10um glutamate

• increase in total and cell surface levels of glutamate receptors

lysosomal protein accumulation ( J:264431 )

• increase in autophagosome/lysosome proteins in spinal motor neuron axons of 9 month old mice

hematopoietic system

microgliosis ( J:264431 )

• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:264431 )

• increased cell death in neurons after treatment with 10um glutamate

• increase in total and cell surface levels of glutamate receptors

immune system

microgliosis ( J:264431 )

• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice

muscle

decreased gastrocnemius weight ( J:264431 )

♂ • decrease in gastrocnemius muscle weight in 24 month old males

skeletal muscle atrophy ( J:264431 )

• myofiber de/regeneration, decrease in size of muscle fiber, and inflammatory cell infiltration of gastrocnemius muscle in 24 month old males

nervous system

increased susceptibility to neuronal excitotoxicity ( J:264431 )

• increased cell death in neurons after treatment with 10um glutamate

• increase in total and cell surface levels of glutamate receptors

microgliosis ( J:264431 )

• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice

astrocytosis ( J:264431 )

• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice

abnormal motor neuron morphology ( J:264431 )

• accumulation of acetylated alpha-tubulin in spinal motor neuron axons of 9 month old mice

decreased motor neuron number ( J:264431 )

• decrease in numbers of spinal motor neurons in lumbar spinal cord in 18 month, but not 9 month old mice

motor neuron degeneration ( J:264431 )

abnormal neuromuscular synapse morphology ( J:264431 )

• neuromuscular junctions (NMJ) in 18 month old mice are partially or fully fragmented

• severe denervation in NMJ of 18 month old mice

limbs/digits/tail

decreased gastrocnemius weight ( J:264431 )

♂ • decrease in gastrocnemius muscle weight in 24 month old males

Genotype
MGI:2684658

cn5

• Allelic Composition: Psen1^tm1Vln/Psen1^tm1Vln; Tg(Thy1-APPLon)2Vln/0; Tg(Thy1-cre)1Vln/0
• Genetic Background: involves: FVB/N

behavior/neurological

abnormal object recognition memory ( J:87229 )

• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system

nervous system phenotype ( J:87229 )

N • no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age

abnormal long-term potentiation ( J:87229 )

• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls

Genotype
MGI:2684657

cn6

• Allelic Composition: Psen1^tm1Vln/Psen1^tm1Vln; Tg(Thy1-cre)1Vln/0
• Genetic Background: involves: FVB/N

behavior/neurological

behavior/neurological phenotype ( J:87229 )

N • mice do not display any behavioral or cognitive deficits

nervous system

nervous system phenotype ( J:87229 )

N • brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age

amyloid beta deposits ( J:87229 )

• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

abnormal long-term potentiation ( J:87229 )

• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism

amyloid beta deposits ( J:87229 )

• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:87229
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:87229