Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Rho)1Wbae transgene insertion 1, Wolfgang Baehr MGI:2686794 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice
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• progressive reduction of both rod and cone photoreceptors with age
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• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
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• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
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• reduction in thickness of the outer nuclear layer
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• ERGs from dark-adapted mutants show a significant reduction in teh amplitudes of a and b waves at P30
• between P30 and P210, the a wave gradually decreases and the b wave is reduced to about 30% of normal
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• progressive reduction of both rod and cone photoreceptors with age
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• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
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• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 4 | DOID:0110372 |
OMIM:613731 |
J:12791 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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