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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa3tm1(cre)Moon
targeted mutation 1, Anne M Moon
MGI:2686838
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bmp4tm4Blh/Bmp4+
Bmp7tm1.1Dgra/Bmp7tm1.1Dgra
Hoxa3tm1(cre)Moon/Hoxa3+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5642274
cn2
 		Hoxa3tm1(cre)Moon/Hoxa3+
Tbx1tm3Bld/Tbx1tm1Bld 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3641322
cn3
 		Fgf8tm1Mrc/Fgf8tm2Mrc
Hoxa3tm1(cre)Moon/Hoxa3+ 		involves: 129/Sv * C57BL/6 MGI:2686876
cn4
 		Fgf8tm1Mrc/Fgf8tm1Moon
Hoxa3tm1(cre)Moon/Hoxa3+ 		involves: 129/Sv * C57BL/6 MGI:2686877
cn5
 		Pdgfratm8Sor/Pdgfratm8Sor
Hoxa3tm1(cre)Moon/Hoxa3+ 		Not Specified MGI:7545278


Genotype
MGI:5642274
cn1
Allelic
Composition		 Bmp4tm4Blh/Bmp4+
Bmp7tm1.1Dgra/Bmp7tm1.1Dgra
Hoxa3tm1(cre)Moon/Hoxa3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm4Blh mutation (0 available); any Bmp4 mutation (23 available)
Bmp7tm1.1Dgra mutation (0 available); any Bmp7 mutation (37 available)
Hoxa3tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system

embryo
sirenomelia ( J:192045 )
• hindlimb fusion

limbs/digits/tail
sirenomelia ( J:192045 )
• hindlimb fusion

renal/urinary system




Genotype
MGI:3641322
cn2
Allelic
Composition		 Hoxa3tm1(cre)Moon/Hoxa3+
Tbx1tm3Bld/Tbx1tm1Bld
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
Tbx1tm1Bld mutation (1 available); any Tbx1 mutation (36 available)
Tbx1tm3Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
persistent truncus arteriosus ( J:110620 )
• at E18.5 embryos are found to display PTA




Genotype
MGI:2686876
cn3
Allelic
Composition		 Fgf8tm1Mrc/Fgf8tm2Mrc
Hoxa3tm1(cre)Moon/Hoxa3+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1Mrc mutation (0 available); any Fgf8 mutation (21 available)
Fgf8tm2Mrc mutation (0 available); any Fgf8 mutation (21 available)
Hoxa3tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87304 )
• 30% die during the neonatal period because of lethal cardiovascular malformations

cardiovascular system
abnormal pharyngeal arch artery morphology ( J:87304 )
• pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery
abnormal truncus arteriosus septation ( J:87304 )
• only 1 of 33 have severe perturbation of outflow tract septation and alignment (Tetralogy of Fallot and BAV)
abnormal coronary vessel morphology ( J:87304 )
• coronary vascular defects
bicuspid aortic valve ( J:87304 )
• 23% exhibit bicuspid aortic valves

hematopoietic system
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

endocrine/exocrine glands
abnormal parathyroid gland morphology ( J:87304 )
• parathyroid ectopy, hypoplasia, and aplasia
absent parathyroid glands ( J:87304 )
• parathyroid gland aplasia
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

immune system
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

craniofacial
abnormal pharyngeal arch artery morphology ( J:87304 )
• pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery

embryo
abnormal pharyngeal arch artery morphology ( J:87304 )
• pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery
abnormal neural crest cell apoptosis ( J:87304 )
• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

cellular
abnormal neural crest cell apoptosis ( J:87304 )
• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8




Genotype
MGI:2686877
cn4
Allelic
Composition		 Fgf8tm1Mrc/Fgf8tm1Moon
Hoxa3tm1(cre)Moon/Hoxa3+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1Moon mutation (1 available); any Fgf8 mutation (21 available)
Fgf8tm1Mrc mutation (0 available); any Fgf8 mutation (21 available)
Hoxa3tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87304 )
• 30% die during the neonatal period because of lethal cardiovascular malformations

cardiovascular system
abnormal pharyngeal arch artery morphology ( J:87304 )
• exhibit pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery
abnormal truncus arteriosus septation ( J:87304 )
• only 1 of 33 have severe perturbation of outflow tract septation and alignment (Tetralogy of Fallot and BAV)
abnormal coronary vessel morphology ( J:87304 )
• coronary vascular defects
bicuspid aortic valve ( J:87304 )
• 23% exhibit bicuspid aortic valves

hematopoietic system
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

endocrine/exocrine glands
abnormal parathyroid gland morphology ( J:87304 )
• parathyroid ectopy, hypoplasia, and aplasia
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

immune system
thymus hypoplasia ( J:87304 )
• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

craniofacial
abnormal pharyngeal arch artery morphology ( J:87304 )
• exhibit pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery

embryo
abnormal pharyngeal arch artery morphology ( J:87304 )
• exhibit pharyngeal arch artery defects
abnormal fourth pharyngeal arch artery morphology ( J:87304 )
• defect in vascular tube formation in the fourth pharyngeal arch
enlarged third pharyngeal arch artery ( J:87304 )
• exhibit an abnormally large third pharyngeal arch artery
abnormal neural crest cell apoptosis ( J:87304 )
• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

cellular
abnormal neural crest cell apoptosis ( J:87304 )
• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8




Genotype
MGI:7545278
cn5
Allelic
Composition		 Pdgfratm8Sor/Pdgfratm8Sor
Hoxa3tm1(cre)Moon/Hoxa3+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
Pdgfratm8Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal dorsal mesocardium morphology ( J:157946 )
• inferior fusion defects resulting in notching of the inferior portion
total anomalous pulmonary venous connection ( J:157946 )
• rare but consistent phenotype




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory