hematopoietic system
• levels of megakaryocyte progenitors reduced by about 50%
• fewer megakaryocytes generated in response to thrombopoietin and the ploidy of cells produced was lower
• less of an increase in platelets 5 days after thrombopoietin treatment
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
congenital amegakaryocytic thrombocytopenia | DOID:0090118 | J:87416 |