Phenotypes associated with this allele

• Allele Symbol: Lpar1^tm1Mcox
• Allele Name: targeted mutation 1, Peter R Maycox
• Allele ID: MGI:2687056
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpar1^tm1Mcox/Lpar1^tm1Mcox	B6.129P2-Lpar1^tm1Mcox	MGI:2687076

Genotype
MGI:2687076

hm1

• Allelic Composition: Lpar1^tm1Mcox/Lpar1^tm1Mcox
• Genetic Background: B6.129P2-Lpar1^tm1Mcox

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:87198 )

• homozygotes are obtained at sub-Mendelian ratios, with most deaths occurring perinatally

postnatal lethality, incomplete penetrance ( J:87198 )

• if unattended, some homozygotes die postnatally, putatively as a result of an impaired ability to feed due to overgrown incisors

behavior/neurological

decreased locomotor activity ( J:87198 )

• homozygotes exhibit a <10% decrease in locomotor activity relative to wild-type littermates

craniofacial

abnormal craniofacial morphology ( J:87198 )

• homozygotes develop a striking craniofacial abnormality that is evident during the second week of life

long incisors ( J:87198 )

• some homozygotes develop overgrown incisors which may impair their ability to feed

short snout ( J:87198 )

• homozygotes display a shortened eye-to-nose tip length

growth/size/body

long incisors ( J:87198 )

• some homozygotes develop overgrown incisors which may impair their ability to feed

short snout ( J:87198 )

• homozygotes display a shortened eye-to-nose tip length

decreased body mass index ( J:87198 )

• homozygotes exhibit a reduced body mass throughout postnatal development and in adulthood

decreased body height ( J:87198 )

• homozygotes are 10-15% shorter than wild-type littermates

vision/eye

ocular hypertelorism ( J:87198 )

• homozygotes display wide set eyes

nervous system

nervous system phenotype ( J:87198 )

N • adult homozygotes appear neuroanatomically normal, with no obvious structural abnormalities in the optic nerve, corpus callosum, or sciatic nerve relative to wild-type littermates

decreased prepulse inhibition ( J:87198 )

• homozygotes exhibit a significant deficit in prepulse inhibition (PPI) relative to wild-type littermates

• male homozygotes display significantly less PPI than wild-type males at 90 dB/4 kHz, 90 dB/12kHz, and 90 dB/20 kHz

• female homozygotes display significantly less PPI than wild-type females at 80 dB/12 kHz, 80 dB/20kHz, 90 dB/12 kHz, and 90 dB/20 kHz

homeostasis/metabolism

abnormal amino acid level ( J:87198 )

• homozygotes display a significant reduction of aspartate and serine levels in the frontal cortex relative to wild-type littermates

• in addition, homozygotes show a significant reduction in the levels of a large number of amino acids in the hippocampus

increased dopamine level ( J:87198 )

• homozygotes display a small but significant increase of dopamine levels in the striatum, but not in any other major brains regions examined

abnormal serotonin level ( J:87198 )

• homozygotes show a significant decrease in 5-HT turnover, with a corresponding decrease in 5-HIAA levels, in the frontal cortex, hippocampus, hypothalamus, and nucleus accumbens but not in the striatum or cerebellum

skeleton

long incisors ( J:87198 )

• some homozygotes develop overgrown incisors which may impair their ability to feed