All Phenotypes Urod<tm1Kush> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Urod^tm1Kush
targeted mutation 1, James P Kushner
MGI:2687172

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Urod^tm1Kush/Urod^tm1Kush	involves: 129S1/Sv * 129X1/SvJ	MGI:2687182
ht2	Urod^tm1Kush/Urod⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2687184
cx3	Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺	involves: C57BL/6J	MGI:2687183

Allelic Composition	Urod^tm1Kush/Urod^tm1Kush
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urod^tm1Kush mutation (0 available); any Urod mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:66704 )

• no fetuses observed between E7.5 and E9.5

Allelic Composition	Urod^tm1Kush/Urod⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urod^tm1Kush mutation (0 available); any Urod mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:66704 )

• hepatic iron concentrations did not differ from those of wild-type mice through 1 year of age, though treatment with iron dextran elicited a significantly higher increase in hepatic iron in mutant mice than in wild-type mice

• urinary porphyrin concentrations did not differ from those of wild-type mice prior to treatment with delta-aminolevulinic acid (ALA), though treatment with either ALA alone or with both ALA and iron elicited significantly higher increases in porphyrin concentrations than in mutant mice than in wild-type mice

Allelic Composition	Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm2Nca mutation (1 available); any Hfe mutation (35 available)
Urod^tm1Kush mutation (0 available); any Urod mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:66704 )

increased porphyrin level ( J:66704 )

• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

increased liver iron level ( J:66704 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
porphyria cutanea tarda		DOID:3132	OMIM:176090 OMIM:176100	J:66704

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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