Phenotypes associated with this allele

• Allele Symbol: Rere^{Gt(PTO26)1Byg}
• Allele Name: gene trap PTO26, BayGenomics
• Allele ID: MGI:2687216
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rere^Gt(PTO26)1Byg/Rere^Gt(PTO26)1Byg	involves: 129P2/OlaHsd	MGI:3026627
ht2	Rere^om/Rere^Gt(PTO26)1Byg	involves: 129P2/OlaHsd * BTBR * C57BL/6J	MGI:3026628

Genotype
MGI:3026627

hm1

• Allelic Composition: Rere^{Gt(PTO26)1Byg}/Rere^{Gt(PTO26)1Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:87046 )

• no homozygous pups were ever born

embryo

embryo phenotype ( J:87046 )

N • this is a hypomorphic allele and expression in homozygotes varied from very severe as seen in Rere homozygotes to apparently normal but embryonically lethal

Genotype
MGI:3026628

ht2

• Allelic Composition: Rere^om/Rere^{Gt(PTO26)1Byg}
• Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87046 )

• regular ratio of homozygotes at E9.5

• by E11.5 no mutant embryos found

• death due to cardiac failure shortly after E9.5

cardiovascular system

failure of heart looping ( J:87046 )

• heart tube fails to loop

embryo

abnormal embryonic tissue morphology ( J:87046 )

• abnormalities appear by E8.25

small first pharyngeal arch ( J:87046 )

• first branchial arch reduced in size with a deficit in mesenchyme

open neural tube ( J:87046 )

• failure of the anterior neural tube to close

abnormal somite development ( J:87046 )

abnormal somite shape ( J:87046 )

abnormal somite size ( J:87046 )

nervous system

open neural tube ( J:87046 )

• failure of the anterior neural tube to close

abnormal telencephalon development ( J:87046 )

• fusion of telencephalic and optic vesicles

vision/eye

abnormal optic vesicle formation ( J:87046 )

• fusion of telencephalic and optic vesicles

craniofacial

small first pharyngeal arch ( J:87046 )

• first branchial arch reduced in size with a deficit in mesenchyme