Phenotypes associated with this allele

• Allele Symbol: Ptpro^tm1Wig
• Allele Name: targeted mutation 1, Roger C Wiggins
• Allele ID: MGI:2687220
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpro^tm1Wig/Ptpro^tm1Wig	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2687237

Genotype
MGI:2687237

hm1

• Allelic Composition: Ptpro^tm1Wig/Ptpro^tm1Wig
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Glomeruli podocyte abnormalities in Ptpro^tm1Wig/Ptpro^tm1Wig mice

cardiovascular system

abnormal cardiovascular system physiology ( J:65903 )

• while blood pressure is normal in non-nephrectomized mutants, a predisposition to hypertension is identified by nephroectomy

renal/urinary system

abnormal podocyte morphology ( J:65903 )

• ""amoeboid"" structure rather than the ""octopoid"" structure observed in wild-type

abnormal podocyte foot process morphology ( J:65903 )

• foot processes appear shortened and thickened (toelike) compared to thin, even fingerlike processes in wild-type

abnormal renal glomerulus morphology ( J:65903 )

• though glomerular structure is normal at the light microscopic level, scanning and transmission electron imagery revealed podocyte abnormalities

• reduction in the number of intercellular junctions per unit of glomerular basement membrane length

decreased renal glomerular filtration rate ( J:65903 )

• uninephrectomized mice (to reduce renal reserve) have 25-50% lower glomerular filtration rate