All Phenotypes Gadd45b<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gadd45b^tm1Flv/Gadd45b^tm1Flv	B6.129S6-Gadd45b^tm1Flv	MGI:3839941
hm2	Gadd45b^tm1Flv/Gadd45b^tm1Flv	involves: 129S6/SvEvTac	MGI:2687356
cx3	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3839902
cx4	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839942

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:118837 )

• nave and Th1 CD4⁺ T cells have a higher rate of proliferation when activated in vitro

spleen hyperplasia ( J:118837 )

• mice develop mild splenomegaly around 10 months of age

abnormal T-helper 1 physiology ( J:118837 )

• Th1 T cells proliferate at a faster rate when activated in vitro

• proliferation rate is increased even more when Th1 cells are activated in the presence of IL-12 and IL-18

• Th1 T cells are resistant to activation-induced cell death caused by TCR stimulus without co-stimulation

• there is increased production of IFN-gamma by transplanted mutant T cells in the central nervous system of immunocompromised mice that have induced EAE

increased interferon-gamma secretion ( J:118837 )

• there is increased production of IFN-gamma by transplanted mutant T cells in the central nervous system of immunocompromised mice that have induced EAE

increased susceptibility to experimental autoimmune encephalomyelitis ( J:118837 )

• mice have a longer duration of peak disease than controls when mice are immunized with MOG peptide and a low dose of adjuvant

• 60% of mice die compared to none of controls when mice have EAE induced with MOG peptide and a high dose of adjuvant

• 100% of immunocompromised mice transplanted with mutant CD4⁺ T cells develop EAE after immunization compared to 43% of mice that were recipients of wild-type mice

• 71% of mice transplanted with mutant CD4⁺ T cells die from EAE after immunization compared to 14% for hosts with wild-type CD4⁺ T cells

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal/urinary system

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal glomerular immunoglobulin deposits ( J:118837 )

hematopoietic system

increased T cell proliferation ( J:118837 )

• nave and Th1 CD4⁺ T cells have a higher rate of proliferation when activated in vitro

spleen hyperplasia ( J:118837 )

• mice develop mild splenomegaly around 10 months of age

abnormal T-helper 1 physiology ( J:118837 )

• Th1 T cells proliferate at a faster rate when activated in vitro

• proliferation rate is increased even more when Th1 cells are activated in the presence of IL-12 and IL-18

• Th1 T cells are resistant to activation-induced cell death caused by TCR stimulus without co-stimulation

• there is increased production of IFN-gamma by transplanted mutant T cells in the central nervous system of immunocompromised mice that have induced EAE

cellular

increased T cell proliferation ( J:118837 )

• nave and Th1 CD4⁺ T cells have a higher rate of proliferation when activated in vitro

growth/size/body

spleen hyperplasia ( J:118837 )

• mice develop mild splenomegaly around 10 months of age

Allelic Composition	Gadd45b^tm1Flv/Gadd45b^tm1Flv
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45b^tm1Flv mutation (1 available); any Gadd45b mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 cell differentiation ( J:87396 )

• there is a 2- to 3- fold reduction in the number of Th1 T cells produced in vivo after immunization with keyhole limpet hemocyanin

• similar reductions in Th1 T cell production are found after infection with Listera monocytogenes

abnormal CD4-positive, alpha-beta T cell physiology ( J:87396 )

• IL-2 secretion by nave CD4 T cells is about one-third of that in controls

abnormal T-helper 1 physiology ( J:87396 )

• IL-2 secretion by Th1-polarized CD4 T cells is about one-third of that in controls

• IFN-gamma secretion by Th1-polarized CD4 T cells is also reduced greatly

abnormal T-helper 2 physiology ( J:87396 )

• polarized Th2 CD4 T cells secrete about half as much IL-4 as controls

abnormal dendritic cell physiology ( J:87396 )

• dendritic cells produce less IL-6 and IL-12 after activation by low doses of LPS

decreased interferon-gamma secretion ( J:87396 )

• IFN-gamma secretion by Th1-polarized CD4 T cells is about one-fifth of that in controls

• reductions in IFN-gamma secretion are more dramatic when Th1 T cells are stimulated with IL-12 and IL-18 compared to controls

decreased interleukin-12 secretion ( J:87396 )

• there is a large reduction in IL-12 production by dendritic cells after low dose LPS stimulation

decreased interleukin-2 secretion ( J:87396 )

• IL-2 secretion by nave CD4 T cells is about one-third of that in controls

• similar defects in IL-2 secretion are observed for Th1-polarized CD4 T cells

decreased interleukin-4 secretion ( J:87396 )

• polarized Th2 CD4 T cells secrete about half as much IL-4 as controls

decreased interleukin-6 secretion ( J:87396 )

• there is a large reduction in IL-6 production by dendritic cells after low dose LPS stimulation

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:87396 )

• there is a 2- to 3- fold reduction in the number of Th1 T cells produced in vivo after immunization with keyhole limpet hemocyanin

• similar reductions in Th1 T cell production are found after infection with Listera monocytogenes

abnormal CD4-positive, alpha-beta T cell physiology ( J:87396 )

• IL-2 secretion by nave CD4 T cells is about one-third of that in controls

abnormal T-helper 1 physiology ( J:87396 )

• IL-2 secretion by Th1-polarized CD4 T cells is about one-third of that in controls

• IFN-gamma secretion by Th1-polarized CD4 T cells is also reduced greatly

abnormal T-helper 2 physiology ( J:87396 )

• polarized Th2 CD4 T cells secrete about half as much IL-4 as controls

Allelic Composition	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45b^tm1Flv mutation (1 available); any Gadd45b mutation (12 available)
Gadd45g^tm1Flv mutation (1 available); any Gadd45g mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 cell differentiation ( J:87396 )

• Th1 T cell production is severely reduced after infection with Listera monocytogenes compared to controls

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:87396 )

• Th1 T cell production is severely reduced after infection with Listera monocytogenes compared to controls

Allelic Composition	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells

increased mature B cell number ( J:118837 )

• increased mature B cell numbers are found in the spleen of 10 month old mice

increased memory T cell number ( J:118837 )

• increased memory/effector (CD4⁺ CD44⁺) T cells are found in the spleen of 10 month old mice

increased IgG1 level ( J:118837 )

• sera levels of IgG1 are 10-fold higher in mice 10 months of age

increased IgM level ( J:118837 )

• sera levels of IgM are 10-fold higher in mice 10 months of age

increased anti-double stranded DNA antibody level ( J:118837 )

• a large amount of anti-dsDNA IgM and IgG1 is found in the sera of 10 month old mice

increased anti-histone antibody level ( J:118837 )

• a large amount of anti-histone IgM and IgG1 is found in the sera of 10 month old mice

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal/urinary system

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal glomerular immunoglobulin deposits ( J:118837 )

hematopoietic system

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells

increased mature B cell number ( J:118837 )

• increased mature B cell numbers are found in the spleen of 10 month old mice

increased memory T cell number ( J:118837 )

• increased memory/effector (CD4⁺ CD44⁺) T cells are found in the spleen of 10 month old mice

increased IgG1 level ( J:118837 )

• sera levels of IgG1 are 10-fold higher in mice 10 months of age

increased IgM level ( J:118837 )

• sera levels of IgM are 10-fold higher in mice 10 months of age

growth/size/body

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells

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