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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rorctm2Litt
targeted mutation 2, Dan R Littman
MGI:3026635
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rorctm2Litt/Rorctm2Litt involves: 129P2/OlaHsd MGI:3026645
cx2
 		Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4357864
cx3
 		Ltatm1Dch/Ltatm1Dch
Rorctm2Litt/Rorc+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3054104


Genotype
MGI:3026645
hm1
Allelic
Composition		 Rorctm2Litt/Rorctm2Litt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorctm2Litt mutation (2 available); any Rorc mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased thymocyte apoptosis ( J:87395 )
• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours
decreased double-negative T cell number ( J:91566 )
• numbers of intestinal alpha beta T cells including CD4-CD8- cells are significantly reduced
decreased double-positive T cell number ( J:87395 )
• fewer double-positive T cells (30-50% that of wild-type)
decreased NK cell number ( J:142654 )
• the percentage and absolute numbers of the Ncr(NKp46)+CD127+NK1.1- subset of intestinal natural killer cells is strongly decreased compared to controls
• however, the number of NK1.1+ subset of intestinal natural killer cells is normal
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:91566 )
• numbers of intestinal alpha beta T cells including CD4+ cells are significantly reduced
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:91566 )
• numbers of intestinal alpha beta T cells including CD8alpha-beta+ and CD8alpha-alpha+ cells are significantly reduced

immune system
increased thymocyte apoptosis ( J:87395 )
• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours
decreased double-negative T cell number ( J:91566 )
• numbers of intestinal alpha beta T cells including CD4-CD8- cells are significantly reduced
decreased double-positive T cell number ( J:87395 )
• fewer double-positive T cells (30-50% that of wild-type)
decreased NK cell number ( J:142654 )
• the percentage and absolute numbers of the Ncr(NKp46)+CD127+NK1.1- subset of intestinal natural killer cells is strongly decreased compared to controls
• however, the number of NK1.1+ subset of intestinal natural killer cells is normal
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:91566 )
• numbers of intestinal alpha beta T cells including CD4+ cells are significantly reduced
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:91566 )
• numbers of intestinal alpha beta T cells including CD8alpha-beta+ and CD8alpha-alpha+ cells are significantly reduced
abnormal lymph organ development ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells
abnormal gut-associated lymphoid tissue morphology ( J:87395 , J:91566 )
• absence of lymphoid tissue inducer (LTi) cells (J:87395)
• intestinal cryptopatches and isolated lymphoid follicles are absent (J:91566)
absent lymph nodes ( J:87395 )
• mice lack all lymph nodes

cellular
increased thymocyte apoptosis ( J:87395 )
• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours

endocrine/exocrine glands
increased thymocyte apoptosis ( J:87395 )
• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours




Genotype
MGI:4357864
cx2
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (21 available)
Rorctm2Litt mutation (2 available); any Rorc mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system cell morphology ( J:87395 )
• lack of CD11b+ cells in E16.5 fetuses
abnormal lymph organ development ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells
abnormal gut-associated lymphoid tissue morphology ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells




Genotype
MGI:3054104
cx3
Allelic
Composition		 Ltatm1Dch/Ltatm1Dch
Rorctm2Litt/Rorc+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltatm1Dch mutation (2 available); any Lta mutation (17 available)
Rorctm2Litt mutation (2 available); any Rorc mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal gut-associated lymphoid tissue morphology ( J:91566 )
• mature intestinal cryptopatches fail to form




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory