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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vegfctm1Ali
targeted mutation 1, Kari Alitalo
MGI:3026650
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vegfctm1Ali/Vegfctm1Ali involves: 129S1/Sv * 129X1/SvJ MGI:3805197
hm2
 		Vegfctm1Ali/Vegfctm1Ali involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3026653
ht3
 		Vegfctm1Ali/Vegfc+ involves: 129S1/Sv * 129X1/SvJ MGI:3805198
ht4
 		Vegfctm1Ali/Vegfc+ involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3026664
cx5
 		Vegfdtm1Mach/Vegfdtm1Mach
Vegfctm1Ali/Vegfctm1Ali 		involves: 129S1/Sv * 129X1/SvJ MGI:3805196
cx6
 		Tg(KRT14-Vegfd)1Ali/0
Vegfctm1Ali/Vegfc+ 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3805325
cx7
 		Vegfctm1Ali/Vegfc+
Tg(KRT14-FIGF)2Ali/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3805314


Genotype
MGI:3805197
hm1
Allelic
Composition		 Vegfctm1Ali/Vegfctm1Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal lymphatic vessel morphology ( J:137909 )
• lymph sacs are absent at E13.5
abnormal lymphangiogenesis ( J:137909 )
• sprouting of lymphatic endothelial cells from the jugular vein is arrested at E13.5




Genotype
MGI:3026653
hm2
Allelic
Composition		 Vegfctm1Ali/Vegfctm1Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:87394 )
• approximately half die between E15.5 and E17.5
• none survive to term

homeostasis/metabolism
hydrops fetalis ( J:87394 )
• embyros show severe edema from E12.5

immune system
absent lymphatic vessels ( J:87394 )
• jugular lymph sacs do not form in embryos
• all lymphatic vessels, including the thoracic duct, are absent at later developmental stages




Genotype
MGI:3805198
ht3
Allelic
Composition		 Vegfctm1Ali/Vegfc+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
lymphatic vessel hypoplasia ( J:137909 )
• hypoplastic lymphatic system in the skin




Genotype
MGI:3026664
ht4
Allelic
Composition		 Vegfctm1Ali/Vegfc+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
lymphedema ( J:87394 )
• accumlulation of chylous, milky fluid high in triglycerides in the abdomen
• adults show swelling of the paws
chylous ascites ( J:87394 )
• the stagnant chylous ascites produces an inflammatory response in the abdominal cavity and leads to severe adhesions and fibrosis of the internal organs

immune system
abnormal lymph circulation ( J:87394 )
• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels
• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs
lymphatic vessel hypoplasia ( J:87394 )
• severe but transient hypoplasia of the lymphatic vasculature in newborns

cardiovascular system
abnormal lymph circulation ( J:87394 )
• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels
• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hereditary lymphedema DOID:0050580 OMIM:PS153100
 J:209628




Genotype
MGI:3805196
cx5
Allelic
Composition		 Vegfdtm1Mach/Vegfdtm1Mach
Vegfctm1Ali/Vegfctm1Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
Vegfdtm1Mach mutation (2 available); any Vegfd mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel morphology ( J:137909 )
• lymph sacs are absent at E13.5
abnormal lymphangiogenesis ( J:137909 )
• sprouting of lymphatic endothelial cells from the jugular vein is arrested at E13.5

cardiovascular system
cardiovascular system phenotype ( J:137909 )
N
• unlike mice homozygous for Flt4tm1Ali, blood vessel morphology is similar to wild-type at E11.5

mortality/aging




Genotype
MGI:3805325
cx6
Allelic
Composition		 Tg(KRT14-Vegfd)1Ali/0
Vegfctm1Ali/Vegfc+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Vegfd)1Ali mutation (1 available)
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel morphology ( J:137909 )
• partial rescue of cutaneous lymphatic vascular hypoplasia
• rescue is not as strong as in mice carrying Tg(KRT14-FIGF)2Ali




Genotype
MGI:3805314
cx7
Allelic
Composition		 Vegfctm1Ali/Vegfc+
Tg(KRT14-FIGF)2Ali/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-FIGF)2Ali mutation (0 available)
Vegfctm1Ali mutation (1 available); any Vegfc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
lymphatic vessel hyperplasia ( J:137909 )
• hyperplastic cutaneous lymphatic vasculature
• hyperplasia is not as strong as in transgenic mice wild-type for Vegfc




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory