Phenotypes associated with this allele

• Allele Symbol: Epha4^tm5Kln
• Allele Name: targeted mutation 5, Rudiger Klein
• Allele ID: MGI:3026688
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha4^tm5Kln/Epha4^tm5Kln	involves: 129 * C57BL/6	MGI:3026788
hm2	Epha4^tm5Kln/Epha4^tm5Kln	involves: 129S/SvEv * C57BL/6	MGI:3608665
hm3	Epha4^tm5Kln/Epha4^tm5Kln	involves: 129/Sv * C57BL/6	MGI:3694671
ht4	Epha4^tm5Kln/Epha4^+	involves: 129/Sv * C57BL/6	MGI:3694678

Genotype
MGI:3026788

hm1

• Allelic Composition: Epha4^tm5Kln/Epha4^tm5Kln
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:87398 )

• hopping gait characterized by mirrored limb movement

nervous system

nervous system phenotype ( J:87398 )

N • normal hippocampal architecture

N • normal long term plasticity at CA3-CA1 synapses indicated by normal LTP and LTD

abnormal corticospinal tract morphology ( J:87398 )

• exhibition of mirrored limb movement indicates axons aberrantly crossed the midline boundary of the spinal cord

Genotype
MGI:3608665

hm2

• Allelic Composition: Epha4^tm5Kln/Epha4^tm5Kln
• Genetic Background: involves: 129S/SvEv * C57BL/6

behavior/neurological

abnormal gait ( J:101019 )

• hopping gait

nervous system

ectopic thalamus ( J:101019 )

• in 83% of homozygotes thalamic neurons are located more medially than in wild-type mice

Genotype
MGI:3694671

hm3

• Allelic Composition: Epha4^tm5Kln/Epha4^tm5Kln
• Genetic Background: involves: 129/Sv * C57BL/6

nervous system

abnormal primary somatosensory cortex morphology ( J:115279 )

abnormal barrel cortex morphology ( J:115279 )

• 83% of mice display abnormal thalamocortical (TC) projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters

abnormal innervation ( J:115279 )

• 83% of mice display abnormal thalamocortical (TC) projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters

Genotype
MGI:3694678

ht4

• Allelic Composition: Epha4^tm5Kln/Epha4⁺
• Genetic Background: involves: 129/Sv * C57BL/6

nervous system

abnormal primary somatosensory cortex morphology ( J:115279 )

abnormal barrel cortex morphology ( J:115279 )

• 50% of heterozygotes show similar abnormalities in TC to homozygotes

abnormal innervation ( J:115279 )

• 50% of heterozygotes show similar abnormalities in TC to homozygotes