Phenotypes associated with this allele

• Allele Symbol: Nfya^tm1Mait
• Allele Name: targeted mutation 1, Sankar N Maity
• Allele ID: MGI:3027019
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nfya^tm1Mait/Nfya^tm1.1Mait	involves: C57BL/6	MGI:3840354

Genotype
MGI:3840354

cn1

• Allelic Composition: Nfya^tm1Mait/Nfya^tm1.1Mait
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:87090 )

• embryonic fibroblasts (MEFs) infected with adenovirus expressing Cre recombinase (AdCre) show a marked decrease in the number of cells in S phase compared to controls

• when aphidicolin is used to arrest AdCre infected MEFs at the G1-S boundary and then the cells are released from the block, entry of cells into S phase is decreased (4% of cells) compared to controls (40% of cells)

increased fibroblast apoptosis ( J:87090 )

• MEFs infected with AdCre undergo increased apoptosis compared to control MEFs

decreased fibroblast proliferation ( J:87090 )

• MEFs from E13.5 embryos infected with adenovirus expressing Cre recombinase (AdCre) exhibit a decrease in growth rate in culture