Phenotypes associated with this allele

• Allele Symbol: Dhcr24^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3027024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhcr24^tm1Lex/Dhcr24^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3027033

Genotype
MGI:3027033

hm1

• Allelic Composition: Dhcr24^tm1Lex/Dhcr24^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:87402 )

• the number of mice born was less than expected by Mendelian ratios

adipose tissue

decreased subcutaneous adipose tissue amount ( J:87402 )

abnormal mesenteric fat pad morphology ( J:87402 )

• decreased stores of mesenteric fat

growth/size/body

decreased body size ( J:87402 )

• approximately 25% smaller than wild-type

decreased body weight ( J:87402 )

• whereas female mice reached normal weight by 4 to 5 weeks of age, male mice did not

postnatal growth retardation ( J:87402 )

homeostasis/metabolism

abnormal circulating cholesterol level ( J:87402 )

• desmosterols accounted for approximately 99% of sterols

• tissue levels of cholesterol were nearly completely ablated

decreased circulating cholesterol level ( J:87402 )

• plasma contained nearly no cholesterol

reproductive system

testis degeneration ( J:87402 )

♂ • testis degeneration

female infertility ( J:87402 )

♀

male infertility ( J:87402 )

♂

integument

decreased subcutaneous adipose tissue amount ( J:87402 )

endocrine/exocrine glands

testis degeneration ( J:87402 )

♂ • testis degeneration