Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mre11atm1Jpt targeted mutation 1, John H J Petrini MGI:3027036 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5, E15.5, and P5, mice exhibit resistance to ionizing radiation-induced apoptosis in the retina and dentate gyrus compared to wild-type mice
• ionizing radiation-induced apoptosis in the thymus is reduced compared to in wild-type mice
• however, ionizing radiation-induced apoptosis in the proliferating embryonic ventricular zone is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• checkpoint defects; MEFs fail to arrest or suffer attrition either in S phase or at the G2/M border
(J:87088)
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
(J:103922)
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• mouse embryonic fibroblasts (MEFs) are sensitive to ionizing radiation
(J:87088)
• MEFs exhibit increased sensitivity to ionizing radiation
(J:103922)
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• passage 7 MEFs show chromosomal instability; 43% vs. 19% of wild-type metaphases contain at least 1 aberration and the number of aberrations per metaphase is increased
• 33% of early passage MEFs (p3) and 65% of late passage (greater than 5) MEFs show aberrant metaphases
• translocasions and fusions are seen in 5 of 32 early and 7 of 27 late passage MEFs
• 18% of metaphases in splenocyte cultures exhibit aberrations
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• MEFs are hypersensitive to irradiation-induced chromosome breakage
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• embryonic viability is drastically reduced in homozygous mothers but not in heterozygous intercrosses, indicating a maternal effect on viability
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| N |
• inspite of cell cycle checkpoint failure and chromosomal instability, mice are not prone to malignancy including lymphomagenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in mice with Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microencephaly is rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• survived to birth but died thereafter
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• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked
• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• although some die prematurely, survival time is increased compared to homozygous Rad50tm2Jpt mice, with 24 of 29 alive at 5 months of age with no signs of anemia
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• 4 of 24 develop lymphoma
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• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
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• MEFs exhibit increased sensitivity to ionizing radiation
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| N |
• do not observe hematopoietic cell attrition as in homozygous Rad50 mice, indicating rescue of hematopoietic defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 32 of 49 die before 5 months of age, however survival time is increased compared to homozygous Rad50tm2Jpt mice, as 17 mutants survive past 5 months of age
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• 19 of the 32 mutants that die exhibited hematopoietic attrition
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• 10 of the 32 mutants that die succumb to lymphoma
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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