Analysis Tools
immune system
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• in the absence of infection, homozygotes display normal T cell, B cell, macrophage, and natural killer cell development relative to wild-type control mice
• in response to i.p. inoculation with 5 x 104 PFU murine cytomegalovirus (MCMV), homozygotes display normal resistance to viral infection, with no differences in splenic and liver viral loads at 3 days after inoculation relative to wild-type control mice
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• at 5 days after infection with T. gondii, homozygotes display a modest increase in serum IFN-gamma levels relative to wild-type controls
• in contrast, homozygotes show no differences in serum IFN-gamma levels at 3 days after infection with Listeria monocytogenes
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• at 5 days after infection with T. gondii, homozygotes display a modest increase in serum IL-12 levels relative to wild-type controls
• similarly, homozygotes display increased serum IL-12 levels at 3 days after infection with Listeria monocytogenes
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• in response to i.p. inoculation with 1,000 CFUs of Listeria monocytogenes, homozygotes display rapid death by 5 days after infection, with significantly increased bacterial burdens in liver and spleen at 3 days after infection relative to wild-type control mice which remain viable at 40 days after infection
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• in response to i.p. inoculation with 20 cysts of Toxoplasma gondii (a parasitic protozoan), homozygotes show a complete loss of resistance to the parasite during the acute phase of infection, and die between days 9 and 11 whereas wild-type littermates remain viable at least up to 40 days after infection
• at 5 days after infection with T. gondii, homozygotes display a significant increase in the number of T. gondii infected cells in the peritoneum, indicating an inability to restrict replication of the parasite
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homeostasis/metabolism
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• at 5 days after infection with T. gondii, homozygotes display a modest increase in serum IFN-gamma levels relative to wild-type controls
• in contrast, homozygotes show no differences in serum IFN-gamma levels at 3 days after infection with Listeria monocytogenes
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• at 5 days after infection with T. gondii, homozygotes display a modest increase in serum IL-12 levels relative to wild-type controls
• similarly, homozygotes display increased serum IL-12 levels at 3 days after infection with Listeria monocytogenes
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