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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myod1tm1.1Glh
targeted mutation 1.1, David J Goldhamer
MGI:3027189
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myod1tm1.1Glh/Myod1tm1.1Glh involves: 129 * C57BL/6J MGI:3027251
cx2
 		Myf5tm1Jae/Myf5tm1Jae
Myod1tm1.1Glh/Myod1tm1.1Glh 		involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:3840223
cx3
 		Myf5tm1Jae/Myf5tm1Jae
Myod1tm1.1Glh/Myod1+ 		involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:3840224


Genotype
MGI:3027251
hm1
Allelic
Composition		 Myod1tm1.1Glh/Myod1tm1.1Glh
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myod1tm1.1Glh mutation (0 available); any Myod1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle development ( J:87370 )
• at E11.5, the expression level of and number of cells expressing myogenin is decreased in the branchial arches and limb buds compared to in wild-type mice indicating delayed differentiation
• however, myogenin expression is normal by E12.5




Genotype
MGI:3840223
cx2
Allelic
Composition		 Myf5tm1Jae/Myf5tm1Jae
Myod1tm1.1Glh/Myod1tm1.1Glh
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myod1tm1.1Glh mutation (0 available); any Myod1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle development ( J:87370 )
• trunk musculature is disorganized compared to in wild-type mice
• expression of Myod1 is delayed at E10.5 compared to in wild-type mice
• however, the Pax3-mediated recovery of Myod1 is normal




Genotype
MGI:3840224
cx3
Allelic
Composition		 Myf5tm1Jae/Myf5tm1Jae
Myod1tm1.1Glh/Myod1+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myod1tm1.1Glh mutation (0 available); any Myod1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle development ( J:87370 )
• trunk musculature is disorganized compared to in wild-type mice
• expression of Myod1 is delayed at E10.5 compared to in wild-type mice
• however, the Pax3-mediated recovery of Myod1 is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory