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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp1a2tm3Ling
targeted mutation 3, Jerry B Lingrel
MGI:3027260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atp1a2tm3Ling/Atp1a2tm3Ling involves: 129S6/SvEvTac * Black Swiss MGI:3027298
cx2
Atp1a1tm2Ling/Atp1a1tm2Ling
Atp1a2tm3Ling/Atp1a2tm3Ling
involves: 129S6/SvEvTac * Black Swiss MGI:3527479


Genotype
MGI:3027298
hm1
Allelic
Composition
Atp1a2tm3Ling/Atp1a2tm3Ling
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm3Ling mutation (1 available); any Atp1a2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice are viable, fertile, and exhibit normal cardiovascular function under normal conditions
• the oubain-induced inotropy observed in wild-type mice does not occur in mutant oubain-treated hearts

muscle
• the oubain-induced inotropy observed in wild-type mice does not occur in mutant oubain-treated hearts




Genotype
MGI:3527479
cx2
Allelic
Composition
Atp1a1tm2Ling/Atp1a1tm2Ling
Atp1a2tm3Ling/Atp1a2tm3Ling
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm2Ling mutation (1 available); any Atp1a1 mutation (61 available)
Atp1a2tm3Ling mutation (1 available); any Atp1a2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• ouabain, a glycoside poison that binds to and inhibits the sodium-potassium pump (inhibits Atp1a1 but not Atp1a2 in these mutants), increased cardiac contractility in isolated mutant hearts and resulted in greater positive inotropy than in wild-type
• 3-fold greater increase in the maximal rate of contraction and the rate of contraction at 40 mm Hg than in wild-type after ouabain infusion, however heart function and response of cardiac contraction to beta-adrenergic stimuli was normal under regular conditions (without ouabain)

muscle
• ouabain, a glycoside poison that binds to and inhibits the sodium-potassium pump (inhibits Atp1a1 but not Atp1a2 in these mutants), increased cardiac contractility in isolated mutant hearts and resulted in greater positive inotropy than in wild-type
• 3-fold greater increase in the maximal rate of contraction and the rate of contraction at 40 mm Hg than in wild-type after ouabain infusion, however heart function and response of cardiac contraction to beta-adrenergic stimuli was normal under regular conditions (without ouabain)





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory