Analysis Tools
mortality/aging
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• only 18% of homozygotes are derived from heterozygous intercrosses over a 3-year period, indicating a small deviation from the expected Mendelian ratio
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behavior/neurological
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• homozygotes are hypersensitive to pentamethylenetetrazol (PTZ)-induced seizures, showing a higher number of deaths at 60 min post-treatment as well as reduced latency to both death and tonic seizure relative to wild-type controls
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• homozygotes are less reactive to novelty-induced locomotion in the open field than wild-type controls, showing an overall 45% decrease in traveled path length on day 1 (but not day 2 or 3) of exposure in both the periphery and center of the open field
• however, no differences in home cage locomotor activity or motor coordination (rotarod test) are observed
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• homozygotes show an attenuated response to stress-induced hypophagia relative to wild-type controls (-19.6% vs -36.4%, respectively), exhibiting a +24% increase in food intake during the first 24 hrs after an acute restraint stress (no food/water for 110 min) but resuming normal (baseline) consumption levels at 48 hrs after stress
(J:87451)
• whether fed or food-deprived, BIMU8-treated mice fail to exhibit reduced food intake unlike in wild-type mice
(J:125754)
• MDMA treated mice fail to exhibit a suppression in appetite unlike wild-type mice
(J:125754)
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• homozygotes spend significantly less time in the center of an open field during day 1 and 2 (but not day 3) of exposure than wild-type controls, suggesting a slight hyperanxiety-like behavior
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nervous system
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• homozygotes are hypersensitive to pentamethylenetetrazol (PTZ)-induced seizures, showing a higher number of deaths at 60 min post-treatment as well as reduced latency to both death and tonic seizure relative to wild-type controls
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growth/size/body
| N |
• at 4 months of age, homozygotes display normal baseline eating and drinking behavior in their home cages
(J:87451)
• no differences in social behavior, aggression, or sleep are observed relative to age-matched controls
(J:87451)
• mice exhibit normal body weight after 3 days of habituation or 24 h food deprivation
(J:125754)
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• unlike wild-type controls, homozygotes fail to display a significant body weight loss during the first 4 days of recovery from an acute restraint stress
• however, no difference in body weight is observed between unrestrained wild-type and mutant mice during development or at 4 months of age
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adipose tissue
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• after restraint stress, homozygotes display a lower white adipose tissue weight/body weight ratio than wild-type controls (-38%), with no difference in their total body weight
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homeostasis/metabolism
| N |
• no difference in corticosterone levels is noted between wild-type and mutant mice before or after the elevated plus maze
• normal metabolic parameters (feces, urine) are observed at 4 months of age
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• whether fed or food-deprived, BIMU8-treated mice fail to exhibit reduced food intake unlike in wild-type mice
• MDMA treated mice fail to exhibit a suppression in appetite unlike wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| anorexia nervosa | DOID:8689 | J:125754 | ||
