All Phenotypes Btla<tm1Kmm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btla^tm1Kmm/Btla^tm1Kmm	B6.129S-Btla^tm1Kmm	MGI:3706172
hm2	Btla^tm1Kmm/Btla^tm1Kmm	involves: 129S/SvEv	MGI:3027779
cx3	Btla^tm1Kmm/Btla^tm1Kmm Pdcd1^tm1Hon/Pdcd1^tm1Hon	B6.129S-Pdcd1^tm1Hon Btla^tm1Kmm	MGI:3706173
cx4	Btla^tm1Kmm/Btla^tm1Kmm Tg(DO11.10)10Dlo/?	involves: 129S/SvEv * BALB/c * C3H * C57BL/6	MGI:3841449

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell activation ( J:119356 )

• splenocytes in mice receiving a Bm12 to B6 allograft show significantly higher anti-donor responder frequencies when challenged with Bm12 antigen presenting cells

decreased T cell proliferation ( J:119356 )

• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells

increased T cell proliferation ( J:119356 )

• increased proliferation of CD4+ T cells stimulated with MHC class II antigens

• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells

• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens

• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells

decreased interferon-gamma secretion ( J:119356 )

• reduced production of IFNG by alloreactive T cells in response to strong alloactivation (full MHC mismatch)

decreased interleukin-2 secretion ( J:119356 )

• reduced production of IL2 by alloreactive T cells in response to strong alloactivation (full MHC mismatch)

increased length of allograft survival ( J:119356 )

• increases survival of fully MHC-mismatched cardiac allografts (12 +/- 5 days) compared to wild-type (8 +/- 1 days)

• treatment with rapamycin significantly prolongs allograft survival (53 +/- 12 days) compared to treated wild-type (11 +/- 2 days)

hematopoietic system

abnormal T cell activation ( J:119356 )

• splenocytes in mice receiving a Bm12 to B6 allograft show significantly higher anti-donor responder frequencies when challenged with Bm12 antigen presenting cells

decreased T cell proliferation ( J:119356 )

• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells

increased T cell proliferation ( J:119356 )

• increased proliferation of CD4+ T cells stimulated with MHC class II antigens

• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells

• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens

• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells

cellular

decreased T cell proliferation ( J:119356 )

• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells

increased T cell proliferation ( J:119356 )

• increased proliferation of CD4+ T cells stimulated with MHC class II antigens

• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells

• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens

• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells

Allelic Composition	Btla^tm1Kmm/Btla^tm1Kmm
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btla^tm1Kmm mutation (3 available); any Btla mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell proliferation ( J:84084 )

• B cells show a slightly greater proliferative response to stimulation with anti-IgM

increased T cell proliferation ( J:84084 )

• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody

abnormal humoral immune response ( J:84084 )

• 4 weeks after immunization with nitrophenol-conjugated keyhole limpet hemocyanin (NP-KLH), mice show a 3-fold increase in the levels of NP-KLH specific IgG1, IgG2a and IgG2b

increased IgG1 level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

increased IgG2a level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

increased IgG2b level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

increased susceptibility to experimental autoimmune encephalomyelitis ( J:84084 )

• mutants show increased clinical score, earlier onset, and prolonged duration of experimentally induced autoimmune encephalomyelitis compared to wild-type

hematopoietic system

increased B cell proliferation ( J:84084 )

• B cells show a slightly greater proliferative response to stimulation with anti-IgM

increased T cell proliferation ( J:84084 )

• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody

increased IgG1 level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

increased IgG2a level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

increased IgG2b level ( J:84084 )

• 3-fold increase compared to wild-type in response to NP-KLH immunization

cellular

increased B cell proliferation ( J:84084 )

• B cells show a slightly greater proliferative response to stimulation with anti-IgM

increased T cell proliferation ( J:84084 )

• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody

Allelic Composition	Btla^tm1Kmm/Btla^tm1Kmm Pdcd1^tm1Hon/Pdcd1^tm1Hon
Genetic Background	B6.129S-Pdcd1^tm1Hon Btla^tm1Kmm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btla^tm1Kmm mutation (3 available); any Btla mutation (30 available)
Pdcd1^tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment

decreased length of allograft survival ( J:119356 )

• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days)

hematopoietic system

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment

cellular

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment

Allelic Composition	Btla^tm1Kmm/Btla^tm1Kmm Tg(DO11.10)10Dlo/?
Genetic Background	involves: 129S/SvEv * BALB/c * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btla^tm1Kmm mutation (3 available); any Btla mutation (30 available)
Tg(DO11.10)10Dlo mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell proliferation ( J:84084 )

• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs

immune system

increased T cell proliferation ( J:84084 )

• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs

cellular

increased T cell proliferation ( J:84084 )

• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs

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