Phenotypes associated with this allele

• Allele Symbol: Prg2^tm1Nal
• Allele Name: targeted mutation 1, Nancy A Lee
• Allele ID: MGI:3027719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prg2^tm1Nal/Prg2^tm1Nal	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3027721

Genotype
MGI:3027721

hm1

• Allelic Composition: Prg2^tm1Nal/Prg2^tm1Nal
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal eosinophil morphology ( J:65655 )

• although the size and number of granules in eosinophils is unchanged, the intensity of staining of secondary granules is reduced

• the electron dense crystalline core of secondary granules is lacking

• no effect on eosinophil recruitment to airways

immune system

abnormal eosinophil morphology ( J:65655 )

• although the size and number of granules in eosinophils is unchanged, the intensity of staining of secondary granules is reduced

• the electron dense crystalline core of secondary granules is lacking

• no effect on eosinophil recruitment to airways

abnormal inflammatory response ( J:65655 )

respiratory system inflammation ( J:65655 )

• no pulmonary histopathology changes

• attenuated airway response to methacholine but not other stimulae

respiratory system

respiratory system inflammation ( J:65655 )

• no pulmonary histopathology changes

• attenuated airway response to methacholine but not other stimulae