Phenotypes associated with this allele

• Allele Symbol: Gpr37^tm2Gtva
• Allele Name: targeted mutation 2, Glauco Tocchini-Valentini
• Allele ID: MGI:3027995
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr37^tm2Gtva/Gpr37^tm2Gtva	involves: 129P2/OlaHsd * C57BL/6J	MGI:3046862

Genotype
MGI:3046862

hm1

• Allelic Composition: Gpr37^tm2Gtva/Gpr37^tm2Gtva
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:91390 )

• fell off in a rotarod test more rapidly than did controls

abnormal locomotor behavior ( J:91390 )

• increased amphetamine induced motor activity

decreased locomotor activity ( J:91390 )

• reduced spontaneous locomotor activity in an open field test

nervous system

abnormal substantia nigra morphology ( J:91390 )

• tyrosine hydroxylase neurons show increased resistance to degeneration due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

homeostasis/metabolism

decreased dopamine level ( J:91390 )

• reduced about 10% in the nigrostriatal dopamine pathway