All Phenotypes Gnai1<tm1Drs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnai1^tm1Drs
targeted mutation 1, Daniel R Storm
MGI:3028010

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnai1^tm1Drs/Gnai1^tm1Drs	Not Specified	MGI:3028104
ht2	Gnai1^tm1Drs/Gnai1⁺	Not Specified	MGI:3028106
cx3	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv	MGI:3710144
cx4	Gnai1^tm1Drs/Gnai1⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv	MGI:5471655
cx5	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai2^tm1Lbi/Gnai2^tm1Lbi	involves: 129S7/SvEvBrd	MGI:5471657

Allelic Composition	Gnai1^tm1Drs/Gnai1^tm1Drs
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1^tm1Drs mutation (0 available); any Gnai1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:87423 )

• hippocampal long term memory was perturbed

• spatial memory was normal as determined by a Morris water maze test

abnormal associative learning ( J:87423 )

• cued auditory training and memory extinction were normal

abnormal passive avoidance behavior ( J:87423 )

• partial loss of memory at 24 hours

• complete loss of memory by 8 days

abnormal contextual conditioning behavior ( J:87423 )

• memory defects in contextual training

abnormal long-term object recognition memory ( J:87423 )

• object recognition was compromised

nervous system

abnormal long-term potentiation ( J:87423 )

• early phase LTP unaffected

• late phase LTP more persistent

Allelic Composition	Gnai1^tm1Drs/Gnai1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1^tm1Drs mutation (0 available); any Gnai1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:87423 )

• hippocampal long term memory was perturbed

• spatial memory was normal as determined by a Morris water maze test

abnormal associative learning ( J:87423 )

• cued auditory training and memory extinction were normal

abnormal passive avoidance behavior ( J:87423 )

• partial memory loss at 24 hours

abnormal long-term object recognition memory ( J:87423 )

• object recognition was compromised

nervous system

abnormal long-term potentiation ( J:87423 )

• early phase LTP unaffected

• late phase LTP persistence intermediate between homozygotes and wild-type mice

Allelic Composition	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1^tm1Drs mutation (0 available); any Gnai1 mutation (15 available)
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

immune system

decreased interleukin-10 secretion ( J:104683 )

• decrease in IL-10 production from peritoneal monocytes after in vitro lipopolysaccharide-induction

increased tumor necrosis factor secretion ( J:104683 )

• increase in TNFa production from spleen monocytes after in vitro lipopolysaccharide-induction

homeostasis/metabolism

abnormal thromboxane level ( J:104683 )

• decreased thromboxane production B2 from peritoneal monocytes after in vitro lipopolysaccharide-induction

skeleton

sternebra fusion ( J:193170 )

asymmetric sternocostal joints ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in ice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai1^tm1Drs/Gnai1⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton

sternebra fusion ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in mice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai2^tm1Lbi/Gnai2^tm1Lbi
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1^tm1Drs mutation (0 available); any Gnai1 mutation (15 available)
Gnai2^tm1Lbi mutation (1 available); any Gnai2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton

skeleton phenotype ( J:193170 )

N	• no rib fusions are detected

abnormal sternocostal joint morphology ( J:193170 )

• one mouse has the eighth rib ectopically attached to the sternum

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