Phenotypes associated with this allele

• Allele Symbol: Was^tm1Kas
• Allele Name: targeted mutation 1, Katherine A Siminovitch
• Allele ID: MGI:3028420
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Was^tm1Kas/Was^tm1Kas	involves: 129/Sv * C57BL/6	MGI:3028422

Genotype
MGI:3028422

hm1

• Allelic Composition: Was^tm1Kas/Was^tm1Kas
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:87875 )

♀ • thymus particularly affected

♀ • about one quarter the normal number of thymocytes

thrombocytopenia ( J:87875 )

♀ • platelet count reduced to 40% of normal

decreased lymphocyte cell number ( J:87875 )

♀

decreased B cell number ( J:87875 )

♀ • B220+. sIgM+ B cells reduced about 50%

decreased T cell number ( J:87875 )

♀ • CD4+ and CD8+ cells reduced 50%

decreased double-positive T cell number ( J:87875 )

♀ • severely reduced numbers of double positive thymocytes

immune system

thymus hypoplasia ( J:87875 )

♀ • thymus particularly affected

♀ • about one quarter the normal number of thymocytes

decreased lymphocyte cell number ( J:87875 )

♀

decreased B cell number ( J:87875 )

♀ • B220+. sIgM+ B cells reduced about 50%

decreased T cell number ( J:87875 )

♀ • CD4+ and CD8+ cells reduced 50%

decreased double-positive T cell number ( J:87875 )

♀ • severely reduced numbers of double positive thymocytes

lymphoid hypoplasia ( J:87875 )

♀ • lymphocyte cellularity reduced in all lymph organs

endocrine/exocrine glands

thymus hypoplasia ( J:87875 )

♀ • thymus particularly affected

♀ • about one quarter the normal number of thymocytes