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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Birc5tm1Wnt
targeted mutation 1, Astar Winoto
MGI:3028474
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Birc5tm1Wnt/Birc5tm1Emc
Tg(Lck-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3028491
cn2
 		Birc5tm1Wnt/Birc5tm1Emc
Tg(Cd4-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3028493


Genotype
MGI:3028491
cn1
Allelic
Composition		 Birc5tm1Wnt/Birc5tm1Emc
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (20 available)
Birc5tm1Wnt mutation (0 available); any Birc5 mutation (20 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal
increased double-negative T cell number ( J:87435 )
• most thymocytes are double negative
• a lower percentage of double negative stage 4 cells (DN4) and increase in DN3 cells
decreased T cell number ( J:87435 )
• only moderate reductions in mature T cells in spleen and lymph nodes
decreased double-positive T cell number ( J:87435 )
• absolute numbers of double positive cells reduced

immune system
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal
increased double-negative T cell number ( J:87435 )
• most thymocytes are double negative
• a lower percentage of double negative stage 4 cells (DN4) and increase in DN3 cells
decreased T cell number ( J:87435 )
• only moderate reductions in mature T cells in spleen and lymph nodes
decreased double-positive T cell number ( J:87435 )
• absolute numbers of double positive cells reduced
small lymph nodes ( J:87435 )
• lymph nodes reduced 50%

endocrine/exocrine glands
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal




Genotype
MGI:3028493
cn2
Allelic
Composition		 Birc5tm1Wnt/Birc5tm1Emc
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (20 available)
Birc5tm1Wnt mutation (0 available); any Birc5 mutation (20 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:87435 )
• peripheral T cells are less mature
• reduction of mature T cells in spleen and lymph nodes

immune system
abnormal T cell differentiation ( J:87435 )
• peripheral T cells are less mature
• reduction of mature T cells in spleen and lymph nodes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory