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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C5ar1tm1Raw
targeted mutation 1, Rick A Wetsel
MGI:3028524
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C5ar1tm1Raw/C5ar1tm1Raw B6.Cg-C5ar1tm1Raw MGI:3811741
hm2
 		C5ar1tm1Raw/C5ar1tm1Raw involves: C57BL/6J MGI:3028526


Genotype
MGI:3811741
hm1
Allelic
Composition		 C5ar1tm1Raw/C5ar1tm1Raw
Genetic
Background		 B6.Cg-C5ar1tm1Raw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Raw mutation (0 available); any C5ar1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:139786 )
N
• mice are normally susceptible to experimentally induced autoimmune myasthenia gravis and normal antibody and lymphocyte proliferation in response
increased spleen germinal center number ( J:139786 )
• in response to induction of experimentally induced autoimmune myasthenia gravis

hematopoietic system
increased spleen germinal center number ( J:139786 )
• in response to induction of experimentally induced autoimmune myasthenia gravis




Genotype
MGI:3028526
hm2
Allelic
Composition		 C5ar1tm1Raw/C5ar1tm1Raw
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Raw mutation (0 available); any C5ar1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:86845 )
N
• antiphospholipid antibodies did not cause an increase in fetal resorption in homozygotes as they did in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory