Analysis Tools
cellular
azoospermia
(
J:87579
)
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• cases of moderate to severe defects in spermatogenesis resulted in azoospermia
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endocrine/exocrine glands
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• reduced nipple size in females
• however, mammary glands were apparently normal
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• testis weight severely reduced at 12 weeks of age
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hematopoietic system
| N |
• hematological, blood clotting and biochemical parameters were all normal in the F2 generation
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reproductive system
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• defects varied from mild to severe in younger F2 males
• apoptosis in stage 12 meiotic cells during spermatogenesis
• 7 month old F2 males and all F3 males showed no abnormalities in spermatogenesis
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azoospermia
(
J:87579
)
|
|
• cases of moderate to severe defects in spermatogenesis resulted in azoospermia
|
|
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• testis weight severely reduced at 12 weeks of age
|
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• epididymis weight slightly reduced
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• F2 and F3 females mated to wild-type males were fertile with normal sized litters and normal gestation periods although delivery problems occasionally occured
• only 1 in 3 F1 females gave birth to live pups
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• only 1 in 3 F1 females gave birth to live pups
• all pups dead by 48 hours with no milk in their stomachs, unable to nurse due to maternal nipple defects
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• 33% pregnancy rate when 11 week F2 males mated to wild-type females
• 65% pregnancy rate when 4.5-7 month F2 males or any later generation adult males were mated to wild-type females
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integument
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• reduced nipple size in females
• however, mammary glands were apparently normal
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