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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adam19Gt(Betageo)1Bbl
gene trap 1, Carl P Blobel
MGI:3028702
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3028708
cx2
Adam15tm1Bbl/Adam15tm1Bbl
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3654839
cx3
Adam17tm1Imx/Adam17tm1Imx
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3654837
cx4
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Adam9tm1Bbl/Adam9tm1Bbl
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3654838
cx5
Adam12tm1Asf/Adam12tm1Asf
Adam15tm1Bbl/Adam15tm1Bbl
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Adam9tm1Bbl/Adam9tm1Bbl
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3654840


Genotype
MGI:3028708
hm1
Allelic
Composition
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam19Gt(Betageo)1Bbl mutation (1 available); any Adam19 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 4 of 5 adult pregnant females died late in pregnancy
• about 80% die in the first days after birth

cardiovascular system
• frequently see extensive vacuolization of endothelial cells
• blood vessels within the myocardium appear abnormal with disrupted smooth muscle cell ensheathment
• neonates exhibit moderate malrotation of the cardiac outflow tracts
• neonates exhibit moderate malrotation of the cardiac outflow tracts, in some cases resulting in an overriding aorta
• about 1/3 of homozygotes show atrial septal defects
• about 1/2 of homozygotes show thickened tricuspid valves, however mitral valves appear normal
• membranous ventricular septal defects (J:87592)
• stenotic aortic valves with abnormally thickened leaflets at birth
• thicker aortic valve
• stenotic pulmonic valves with abnormally thickened leaflets at birth
• exhibit abnormally distended blood-filled vascular structures on the anterior wall of the right ventricle
• those surviving to adulthood display an enlarged right ventricle
• intramyocardial hemorrhage
• occasionally see rupture of both capillaries and arterioles with release of erythrocytes into the extravascular space

muscle
• blood vessels within the myocardium appear abnormal with disrupted smooth muscle cell ensheathment

homeostasis/metabolism
• frequently see perivascular edema in capillaries

skeleton
N
• in spite of high expression in osteoblast-like cells in the bone, neither skeletal development nor bone growth were overtly affected




Genotype
MGI:3654839
cx2
Allelic
Composition
Adam15tm1Bbl/Adam15tm1Bbl
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19Gt(Betageo)1Bbl mutation (1 available); any Adam19 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• thicker and misshapen tricuspid valve, similar to that seen in single homozygous Adam 19 mutants, however have normal mitral vavles and do not exhibit double outlet right ventricle




Genotype
MGI:3654837
cx3
Allelic
Composition
Adam17tm1Imx/Adam17tm1Imx
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Imx mutation (0 available); any Adam17 mutation (64 available)
Adam19Gt(Betageo)1Bbl mutation (1 available); any Adam19 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• 6 of 7 embryos at E13.5-14.5 show an underdeveloped myocardial wall, especially of the left ventricle
• 6 of 7 embryos at E13.5-14.5 show severe lack of trabeculation

muscle
• 6 of 7 embryos at E13.5-14.5 show an underdeveloped myocardial wall, especially of the left ventricle
• 6 of 7 embryos at E13.5-14.5 show severe lack of trabeculation




Genotype
MGI:3654838
cx4
Allelic
Composition
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Adam9tm1Bbl/Adam9tm1Bbl
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam19Gt(Betageo)1Bbl mutation (1 available); any Adam19 mutation (78 available)
Adam9tm1Bbl mutation (1 available); any Adam9 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• misshapen mitral valves at E18.5
• enlarged/thickened mitral valves at E18.5
• enlarged/thickened mitral valves at E18.5
• misshapen tricuspid valve, similar to that seen in single homozygous Adam 19 mutants
• thicker tricuspid valve, similar to that seen in single homozygous Adam 19 mutants




Genotype
MGI:3654840
cx5
Allelic
Composition
Adam12tm1Asf/Adam12tm1Asf
Adam15tm1Bbl/Adam15tm1Bbl
Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl
Adam9tm1Bbl/Adam9tm1Bbl
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19Gt(Betageo)1Bbl mutation (1 available); any Adam19 mutation (78 available)
Adam9tm1Bbl mutation (1 available); any Adam9 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• significantly less (4.6%) than the expected Mendelian ratio of 25% of mutants is seen at birth, however normal numbers are seen at E18.5 although less than 1/3 have a visible heartbeat at this time

cardiovascular system
• both the aorta and pulmonic artery emanate from the right ventricle, a more severe malrotation defect than seen in single homozygous Adam19 mutant mice
• exhibit a ventricular septal defect at E18.5
• thicker and misshapen mitral valve
• misshapen tricuspid valve
• hyperplastic tricuspid valve
• hyperplastic semilunar valves





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory