All Phenotypes Adam19<Gt(Betageo)1Bbl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3028708
cx2	Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3654839
cx3	Adam17^tm1Imx/Adam17^tm1Imx Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3654837
cx4	Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3654838
cx5	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3654840

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

pregnancy-related premature death ( J:87592 )

• 4 of 5 adult pregnant females died late in pregnancy

postnatal lethality, incomplete penetrance ( J:87592 )

• about 80% die in the first days after birth

cardiovascular system

abnormal vascular endothelial cell morphology ( J:87592 )

• frequently see extensive vacuolization of endothelial cells

abnormal vascular smooth muscle morphology ( J:87592 )

• blood vessels within the myocardium appear abnormal with disrupted smooth muscle cell ensheathment

abnormal cardiac outflow tract development ( J:87592 )

• neonates exhibit moderate malrotation of the cardiac outflow tracts

overriding aortic valve ( J:87592 )

• neonates exhibit moderate malrotation of the cardiac outflow tracts, in some cases resulting in an overriding aorta

atrial septal defect ( J:87592 )

• about 1/3 of homozygotes show atrial septal defects

abnormal heart valve morphology ( J:87592 )

abnormal tricuspid valve morphology ( J:99649 )

thick tricuspid valve ( J:87592 )

• about 1/2 of homozygotes show thickened tricuspid valves, however mitral valves appear normal

abnormal heart ventricle morphology ( J:87592 )

perimembraneous ventricular septal defect ( J:87592 , J:99649 )

• membranous ventricular septal defects (J:87592)

aortic valve stenosis ( J:87592 )

• stenotic aortic valves with abnormally thickened leaflets at birth

thick aortic valve ( J:99649 )

• thicker aortic valve

thick aortic valve cusps ( J:87592 )

thick pulmonary valve cusps ( J:87592 )

pulmonary valve stenosis ( J:87592 )

• stenotic pulmonic valves with abnormally thickened leaflets at birth

heart right ventricle aneurysm ( J:87592 )

• exhibit abnormally distended blood-filled vascular structures on the anterior wall of the right ventricle

dilated heart right ventricle ( J:87592 )

• those surviving to adulthood display an enlarged right ventricle

hemorrhage ( J:87592 )

• intramyocardial hemorrhage

• occasionally see rupture of both capillaries and arterioles with release of erythrocytes into the extravascular space

muscle

abnormal vascular smooth muscle morphology ( J:87592 )

• blood vessels within the myocardium appear abnormal with disrupted smooth muscle cell ensheathment

homeostasis/metabolism

edema ( J:87592 )

• frequently see perivascular edema in capillaries

skeleton

skeleton phenotype ( J:87592 )

N	• in spite of high expression in osteoblast-like cells in the bone, neither skeletal development nor bone growth were overtly affected

Allelic Composition	Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal tricuspid valve morphology ( J:99649 )

• thicker and misshapen tricuspid valve, similar to that seen in single homozygous Adam 19 mutants, however have normal mitral vavles and do not exhibit double outlet right ventricle

thick tricuspid valve ( J:99649 )

Allelic Composition	Adam17^tm1Imx/Adam17^tm1Imx Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17^tm1Imx mutation (0 available); any Adam17 mutation (64 available)
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:99649 )

• die around E13.5 to E14.5

cardiovascular system

abnormal myocardium layer morphology ( J:99649 )

• 6 of 7 embryos at E13.5-14.5 show an underdeveloped myocardial wall, especially of the left ventricle

absent myocardial trabeculae ( J:99649 )

• 6 of 7 embryos at E13.5-14.5 show severe lack of trabeculation

thin ventricular wall ( J:99649 )

muscle

abnormal myocardium layer morphology ( J:99649 )

• 6 of 7 embryos at E13.5-14.5 show an underdeveloped myocardial wall, especially of the left ventricle

absent myocardial trabeculae ( J:99649 )

• 6 of 7 embryos at E13.5-14.5 show severe lack of trabeculation

Allelic Composition	Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:99649 )

abnormal mitral valve morphology ( J:99649 )

• misshapen mitral valves at E18.5

enlarged mitral valve ( J:99649 )

• enlarged/thickened mitral valves at E18.5

thick mitral valve ( J:99649 )

• enlarged/thickened mitral valves at E18.5

abnormal tricuspid valve morphology ( J:99649 )

• misshapen tricuspid valve, similar to that seen in single homozygous Adam 19 mutants

thick tricuspid valve ( J:99649 )

• thicker tricuspid valve, similar to that seen in single homozygous Adam 19 mutants

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:99649 )

• significantly less (4.6%) than the expected Mendelian ratio of 25% of mutants is seen at birth, however normal numbers are seen at E18.5 although less than 1/3 have a visible heartbeat at this time

cardiovascular system

double outlet right ventricle ( J:99649 )

• both the aorta and pulmonic artery emanate from the right ventricle, a more severe malrotation defect than seen in single homozygous Adam19 mutant mice

ventricular septal defect ( J:99649 )

• exhibit a ventricular septal defect at E18.5

abnormal heart valve morphology ( J:99649 )

abnormal mitral valve morphology ( J:99649 )

• thicker and misshapen mitral valve

thick mitral valve ( J:99649 )

abnormal tricuspid valve morphology ( J:99649 )

• misshapen tricuspid valve

tricuspid valve hyperplasia ( J:99649 )

• hyperplastic tricuspid valve

semilunar valve hyperplasia ( J:99649 )

• hyperplastic semilunar valves

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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