adipose tissue
• adipocytes of smaller size, with a lower lipid content
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• 40% reduction in the weight of the epididymal fat pads
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growth/size/body
N |
• growth and weight gain were normal for the first 6 months of life
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homeostasis/metabolism
• insulin stimulated uptake in both adipocytes and extensor digitorum longus muscle was increased 2X
• resistant to obesity induced hyperinsulinemia
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• fasting mice with lower insulin levels although glucose levels were normal
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• insulin had a greater affect on blood glucose levels in an insulin tolerance test although glucose tolerance tests were normal
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• basal lipogenesis levels in adipocytes were lower
• more robust incorporation of glucose into lactate
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• 25% reduction in body triglyceride levels
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