All Phenotypes Pou2f2<tm1Bal> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou2f2^tm1Bal/Pou2f2^tm1Bal	involves: 129S2/SvPas	MGI:3765426
hm2	Pou2f2^tm1Bal/Pou2f2^tm1Bal	involves: 129S2/SvPas * C57BL/6	MGI:3037267
ht3	Pou2f2^tm1Bal/Pou2f2⁺	involves: 129S2/SvPas	MGI:3765427
cx4	Pou2f1^tm1Shrp/Pou2f1⁺ Pou2f2^tm1Bal/Pou2f2⁺	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3028898

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:4555 )

• within a few hours of birth mice become lethargic, dehydrated, cyanotic and die of unknown causes

• however, lungs, heart, spleen, liver, thymus, kidneys and brain are normal

immune system

decreased mature B cell number ( J:4555 )

• mature B cell numbers in the liver and spleen are slightly lower than in wild-type mice

• however, early B cell and fetal pre-B and B cell numbers are normal

• the frequency of IgM or IgG1 forming clones from cultured liver cells is reduced 20-fold, the frequency of IgG1 forming clones from spleen cells is reduced 100-fold, and the frequency of IgM forming clones from spleen cells is reduced 200-fold compared to wild-type

decreased IgG1 level ( J:4555 )

• cultured liver cells produce 10-fold less IgG1 compared to wild-type

• cultured spleen cells produce 70-fold less IgG1 compared to wild-type

decreased IgM level ( J:4555 )

• cultured liver cells produce 16-fold less IgM compared to wild-type

• cultured spleen cells produce 55-fold less IgM compared to wild-type

homeostasis/metabolism

cyanosis ( J:4555 )

• within a few hours of birth

dehydration ( J:4555 )

• within a few hours of birth

behavior/neurological

lethargy ( J:4555 )

• within a few hours of birth

abnormal suckling behavior ( J:4555 )

• mice do not suckle at birth

respiratory system

respiratory system phenotype ( J:4555 )

N	• at birth, lungs are pink and inflate

hematopoietic system

decreased mature B cell number ( J:4555 )

• mature B cell numbers in the liver and spleen are slightly lower than in wild-type mice

• however, early B cell and fetal pre-B and B cell numbers are normal

decreased IgG1 level ( J:4555 )

• cultured liver cells produce 10-fold less IgG1 compared to wild-type

• cultured spleen cells produce 70-fold less IgG1 compared to wild-type

decreased IgM level ( J:4555 )

• cultured liver cells produce 16-fold less IgM compared to wild-type

• cultured spleen cells produce 55-fold less IgM compared to wild-type

Allelic Composition	Pou2f2^tm1Bal/Pou2f2^tm1Bal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f2^tm1Bal mutation (0 available); any Pou2f2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88240 )

• homozygous mice die shortly after birth

hematopoietic system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear immature with high heat stable antigen levels

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen

immune system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear immature with high heat stable antigen levels

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen

Allelic Composition	Pou2f2^tm1Bal/Pou2f2⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f2^tm1Bal mutation (0 available); any Pou2f2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:4555 )

• mature B cells in the liver are reduced compared to in wild-type mice but not as severely as in homozygous mice

decreased IgG1 level ( J:4555 )

• cultured liver and spleen cells produce less IgG1 than wild-type cells but more than homozygous cells

decreased IgM level ( J:4555 )

• cultured liver and spleen cells produce less IgM than wild-type cells but more than homozygous cells

hematopoietic system

decreased mature B cell number ( J:4555 )

• mature B cells in the liver are reduced compared to in wild-type mice but not as severely as in homozygous mice

decreased IgG1 level ( J:4555 )

• cultured liver and spleen cells produce less IgG1 than wild-type cells but more than homozygous cells

decreased IgM level ( J:4555 )

• cultured liver and spleen cells produce less IgM than wild-type cells but more than homozygous cells

Allelic Composition	Pou2f1^tm1Shrp/Pou2f1⁺ Pou2f2^tm1Bal/Pou2f2⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1^tm1Shrp mutation (1 available); any Pou2f1 mutation (99 available)
Pou2f2^tm1Bal mutation (0 available); any Pou2f2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:87664 )

• many transheterozygous mutants die within 24 hours of birth

postnatal lethality, incomplete penetrance ( J:87664 )

• a subset of mutants surviving birth die prior to weaning

behavior/neurological

lethargy ( J:87664 )

• surviving neonates become increasingly lethargic and runted

growth/size/body

decreased body weight ( J:87664 )

• surviving neonates have lower body weights

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