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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Snj
targeted mutation 1, Stephen N Jones
MGI:3028920
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1Snj/Trp53tm1Snj involves: C57BL/6 MGI:3028927
cx2
 		Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm1Snj/Trp53tm1Snj 		involves: C57BL/6 MGI:3028928


Genotype
MGI:3028927
hm1
Allelic
Composition		 Trp53tm1Snj/Trp53tm1Snj
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Snj mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:87687 )
• highly reduced incidence of spontaneous tumor formation

cellular
decreased cellular sensitivity to ionizing radiation ( J:87687 )
• reduced numbers of thymocytes and splenocytes undergoing apoptosis as a result of ionizing radiation (increased cell viability)




Genotype
MGI:3028928
cx2
Allelic
Composition		 Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm1Snj/Trp53tm1Snj
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (54 available)
Trp53tm1Snj mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:87687 )
• failed to rescue embryonic lethality due to the homozygous Mdm2tm1Bay condition




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory