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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cited1tm1Dunw
targeted mutation 1, Sally L Dunwoodie
MGI:3028946
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cited1tm1Dunw/Cited1tm1Dunw B6.129P2-Cited1tm1Dunw MGI:3029004
hm2
 		Cited1tm1Dunw/Cited1tm1Dunw involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA MGI:3029002
ht3
 		Cited1tm1Dunw/Cited1+ B6.129P2-Cited1tm1Dunw MGI:3029008
ot4
 		Cited1tm1Dunw/Y B6.129P2-Cited1tm1Dunw MGI:3029003
ot5
 		Cited1tm1Dunw/Y involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA MGI:3029001


Genotype
MGI:3029004
hm1
Allelic
Composition		 Cited1tm1Dunw/Cited1tm1Dunw
Genetic
Background		 B6.129P2-Cited1tm1Dunw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87595 )
• when null males are crossed with heterozygous females, null mutants are underrepresented by 78% compared with controls on P28; further analysis indicates lethality within 1 day after birth
• Background Sensitivity: penetrance is increased with contribution from C57BL/6 genetic background

embryo

growth/size/body
decreased birth weight ( J:87595 )
• reduction in body weight relative to controls on day of birth
decreased fetal weight ( J:87595 )
• weigh significantly less at E18.5 than controls

cardiovascular system




Genotype
MGI:3029002
hm2
Allelic
Composition		 Cited1tm1Dunw/Cited1tm1Dunw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87595 )
• incomplete penetrance, with lethality within 1 day after birth
• Background Sensitivity: penetrance increased with contribution from C57BL/6 genetic background

embryo

growth/size/body
decreased birth weight ( J:87595 )
• females are 19% lighter than controls at birth, however they reach normal body weight by 160 days of age
decreased fetal weight ( J:87595 )
• weigh significantly less at E18.5 than controls
• mice reach normal body weight by 160 days of age

cardiovascular system




Genotype
MGI:3029008
ht3
Allelic
Composition		 Cited1tm1Dunw/Cited1+
Genetic
Background		 B6.129P2-Cited1tm1Dunw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87595 )
• loss of heterozygous females at birth (47%) but only when the wild-type allele is inherited from the father

cellular
paternal imprinting ( J:87595 )
• female heterozygotes that inherit a wild-type paternal allele and mutant maternal allele are phenotypically null in extraembryonic ectoderm and endoderm due to inactivation of the the paternal allele and die at or shortly after birth
• female heterozygotes that inherit a mutant paternal allele and a wild-type maternal allele are phenotypically normal

embryo
abnormal placenta morphology ( J:87595 )
• border between the spongiotrophoblast and labyrinthine layers is irregular in females inheriting the mutant allele from the mother and the wild-type allele from the father; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted in female heterozygotes inheriting the mutant allele from the mother and the wild-type allele from the father due to the projection of spongiotrophoblasts into the labyrinthine layer
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants that inherit the mutant allele from the mother and the wild-type allele from the father
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls

growth/size/body
decreased birth weight ( J:87595 )
• birth weight of mice that inherit a mutant maternal allele is reduced
decreased fetal weight ( J:87595 )
• weight of mice that inherit a mutant maternal allele is reduced at E18.5

cardiovascular system
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted in female heterozygotes inheriting the mutant allele from the mother and the wild-type allele from the father due to the projection of spongiotrophoblasts into the labyrinthine layer
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants that inherit the mutant allele from the mother and the wild-type allele from the father
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls




Genotype
MGI:3029003
ot4
Allelic
Composition		 Cited1tm1Dunw/Y
Genetic
Background		 B6.129P2-Cited1tm1Dunw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87595 )
• when wild-type males and heterozygous females are crossed, 82% fewer null males are seen at P28; further analysis indicates lethality within 1 day of birth
• Background Sensitivity: penetrance increases with contribution from C57BL/6 genetic background

embryo
abnormal placenta morphology ( J:87595 )
• border between the spongiotrophoblast and labyrinthine layers is irregular; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
• surface area available for exchange between the fetus and mother is greatly reduced due to increase in size of maternal sinusoids
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
increased spongiotrophoblast size ( J:87595 )
• increase in the size of the spongiotrophoblast layer, however overall size of the placenta is normal
decreased placental labyrinth size ( J:87595 )
• decrease in the size of the labyrinthine layer, however overall size of the placenta is normal
• organization of the labyrinth is disrupted

growth/size/body
decreased birth weight ( J:87595 )
• reduction in body weight relative to controls on day of birth
decreased fetal weight ( J:87595 )
• weigh significantly less at E18.5 than controls

cardiovascular system
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls




Genotype
MGI:3029001
ot5
Allelic
Composition		 Cited1tm1Dunw/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87595 )
• incomplete penetrance; 20% reduction in null mice compared to wild-type
• Background Sensitivity: penetrance increases with contribution from C57BL/6 genetic background

embryo
abnormal placenta morphology ( J:87595 )
• border between the spongiotrophoblast and labyrinthine layers is irregular; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
• surface area available for exchange between the fetus and mother is greatly reduced due to increase in size of maternal sinusoids
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
increased spongiotrophoblast size ( J:87595 )
• increase in the size of the spongiotrophoblast layer, however overall size of the placenta is normal
decreased placental labyrinth size ( J:87595 )
• decrease in the size of the labyrinthine layer, however overall size of the placenta is normal
disorganized placental labyrinth ( J:87595 )
• organization of the labyrinth is disrupted

growth/size/body
decreased birth weight ( J:87595 )
• males are 23% lighter than controls at birth, however they reach normal body weight by 160 days of age
decreased fetal weight ( J:87595 )
• weigh significantly less at E18.5 than controls

cardiovascular system
abnormal placenta vasculature ( J:87595 )
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
abnormal placental labyrinth vasculature morphology ( J:87595 )
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls




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11/12/2024
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