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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhogtm1Tnr
targeted mutation 1, Martin Turner
MGI:3029009
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhogtm1Tnr/Rhogtm1Tnr involves: 129 MGI:3029022


Genotype
MGI:3029022
hm1
Allelic
Composition
Rhogtm1Tnr/Rhogtm1Tnr
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhogtm1Tnr mutation (2 available); any Rhog mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• respond slightly better to antigen receptor triggered stimulation
• elevated serum levels of IgG1 and IgG2b while levels of IgM, IgG2a, IgG3, and IgA were normal
• responses to thymus dependent antigens tended to result in higher levels of specific antibodies
• Il-5 production by Th2 cells decreased

nervous system
N
• neural organization of the brain was normal

hematopoietic system
• respond slightly better to antigen receptor triggered stimulation
• elevated serum levels of IgG1 and IgG2b while levels of IgM, IgG2a, IgG3, and IgA were normal
• responses to thymus dependent antigens tended to result in higher levels of specific antibodies
• Il-5 production by Th2 cells decreased

cellular
• respond slightly better to antigen receptor triggered stimulation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory