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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meis1tm1Ngc
targeted mutation 1, Neal G Copeland
MGI:3029063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Meis1tm1Ngc/Meis1tm1Ngc involves: 129 * C57BL/6NCr MGI:3029085
hm2
 		Meis1tm1Ngc/Meis1tm1Ngc involves: 129S1/SvImJ MGI:3029083


Genotype
MGI:3029085
hm1
Allelic
Composition		 Meis1tm1Ngc/Meis1tm1Ngc
Genetic
Background		 involves: 129 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meis1tm1Ngc mutation (1 available); any Meis1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:87890 )
• Background Sensitivity: death by E14.5 on a mixed genetic background involving 129 and C57BL/6Ncr

cardiovascular system
abnormal capillary morphology ( J:87890 )
• abnormal capillaries that are too narrow to allow red blood cells to pass or that form larger sinuses where red blood cells pool
• larger blood vessels are normal
abnormal capillary branching pattern ( J:87890 )
• branching pattern of capillaries is abnormal
abnormal angiogenesis ( J:87890 )
• irregular and disorganized microvasculature
abnormal vascular branching morphogenesis ( J:87890 )
• branching pattern of capillaries is abnormal
abnormal heart morphology ( J:87890 )
• abnormalities are observed in the heart
hemorrhage ( J:87890 )
• variable but extensive hemorrhaging in the brain and trunk of E13.5 mutants

hematopoietic system
decreased common myeloid progenitor cell number ( J:87890 )
• while definitive myeloerythroid lineages exist, there is a 2- to 5-fold reduction in the total number of colony forming cells
absent megakaryocytes ( J:87890 )
• megakaryocytes are not produced

vision/eye
small lens ( J:87890 )
• observed at E13
abnormal retina morphology ( J:87890 )
• retina is abnormal at E13 and may be partially duplicated

nervous system
abnormal brain morphology ( J:87890 )
• abnormalities are observed in the brain

renal/urinary system
abnormal kidney morphology ( J:87890 )
• abnormalities are observed in the kidney

respiratory system
abnormal lung morphology ( J:87890 )
• abnormalities are observed in the lungs

liver/biliary system
abnormal liver morphology ( J:87890 )
• total cellularity of fetal livers is decreased

limbs/digits/tail
limbs/digits/tail phenotype ( J:87890 )
N
• no obvious limb defects are seen




Genotype
MGI:3029083
hm2
Allelic
Composition		 Meis1tm1Ngc/Meis1tm1Ngc
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meis1tm1Ngc mutation (1 available); any Meis1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:87890 )
• Background Sensitivity: death by E12.5 on a 129 genetic background

cardiovascular system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory