Phenotypes associated with this allele

• Allele Symbol: Grb14^tm1Daly
• Allele Name: targeted mutation 1, Roger J Daly
• Allele ID: MGI:3029164
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grb14^tm1Daly/Grb14^tm1Daly	involves: 129X1/SvJ * C57BL/6	MGI:3029166

Genotype
MGI:3029166

hm1

• Allelic Composition: Grb14^tm1Daly/Grb14^tm1Daly
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:87892 )

• males exhibit increased glucose tolerance between 16 and 24 weeks of age

• circulating level of insulin is lower in males in response to the same glucose load

• males exhibit an increase in glucose incorporation into tissue glycogen

increased insulin sensitivity ( J:87892 )

• decrease in blood glucose than wild-type males

• fasting plasma insulin levels in males are lower at 28-30 and 54-56 weeks of age

• male skeletal muscle and liver exhibits enhanced insulin-induced glucose uptake

cardiovascular system

increased heart weight ( J:87892 )

• 28 week old males exhibit an 18% increase in heart weight

growth/size/body

increased heart weight ( J:87892 )

• 28 week old males exhibit an 18% increase in heart weight

decreased body weight ( J:87892 )

• small but significant decrease in body weight for both males (5-10%) and females (5%)

hematopoietic system

decreased spleen weight ( J:87892 )

• 28 week old males exhibit a disproportionate decrease (29%) in spleen weight

immune system

decreased spleen weight ( J:87892 )

• 28 week old males exhibit a disproportionate decrease (29%) in spleen weight

liver/biliary system

decreased liver weight ( J:87892 )

• 28 week old males exhibit a disproportionate decrease (16%) in liver weight