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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpv1tm1Jbd
targeted mutation 1, John B Davis
MGI:3029186
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpv1tm1Jbd/Trpv1tm1Jbd involves: 129P2/OlaHsd MGI:4458087
hm2
 		Trpv1tm1Jbd/Trpv1tm1Jbd involves: 129P2/OlaHsd * C57BL/6J MGI:3029187


Genotype
MGI:4458087
hm1
Allelic
Composition		 Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jbd mutation (0 available); any Trpv1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sensory neuron physiology ( J:161343 )
• vagal neurons fail to respond to capsaicin unlike similarly treated wild-type mice
• vagal neurons lack response to 100 uM 4-oxononenal (4ONE) unlike similarly treated wild-type cells




Genotype
MGI:3029187
hm2
Allelic
Composition		 Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jbd mutation (0 available); any Trpv1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nociception after inflammation ( J:62074 )
• while mice did not show a prolonged latency in the hot plate test, they did not develop thermal hyperalgesia after induced inflammation by carrageenan injection

nervous system
abnormal nervous system electrophysiology ( J:62074 )
• cultured small dorsal root ganglion neurons lacked capsaicin-, acid-, and heat-gated responses, but exhibited normal responses to gamma-aminobutyric acid and ATP




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory