About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltc4stm1Blam
targeted mutation 1, Bing K Lam
MGI:3029254
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltc4stm1Blam/Ltc4stm1Blam B6.129S7-Ltc4stm1Blam MGI:5517589
hm2
 		Ltc4stm1Blam/Ltc4stm1Blam C.129S7-Ltc4stm1Blam MGI:5316008
hm3
 		Ltc4stm1Blam/Ltc4stm1Blam involves: 129S7/SvEvBrd * BALB/c MGI:3694667
hm4
 		Ltc4stm1Blam/Ltc4stm1Blam involves: 129S7/SvEvBrd * C57BL/6 MGI:3029269


Genotype
MGI:5517589
hm1
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 B6.129S7-Ltc4stm1Blam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis
• however, ear histamine content is normal




Genotype
MGI:5316008
hm2
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 C.129S7-Ltc4stm1Blam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice
• however, dermal infiltration by CD4+ cells and eosinophils is similar to wild-type mice and systemic immune response to EC sensitization with OVA is comparable to wild-type controls

integument
abnormal skin physiology ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice




Genotype
MGI:3694667
hm3
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal type I hypersensitivity reaction ( J:87909 )
• IgE dependent passive cutaneous anaphylaxis significantly reduced
• less swelling




Genotype
MGI:3029269
hm4
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:110309 )
N
• macrophage phagocytosis is normal
respiratory system inflammation ( J:88647 )
• reduced pulmonary inflammation compared to controls 7 days after bleomycin injection
• fewer thickened alveolar septa after bleomycin injection
• decreased extra cellular matrix after bleomycin injection
• decreased clusters of monocytes/macrophage, giant cells, neutrophiles after bleomycin injection
• significantly reduced cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection

cardiovascular system
decreased vascular permeability ( J:87909 )
• reduced vascular permeability as a result of zymosan elicited peritoneal inflammation

respiratory system
respiratory system inflammation ( J:88647 )
• reduced pulmonary inflammation compared to controls 7 days after bleomycin injection
• fewer thickened alveolar septa after bleomycin injection
• decreased extra cellular matrix after bleomycin injection
• decreased clusters of monocytes/macrophage, giant cells, neutrophiles after bleomycin injection
• significantly reduced cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory