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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltc4stm1Blam
targeted mutation 1, Bing K Lam
MGI:3029254
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltc4stm1Blam/Ltc4stm1Blam B6.129S7-Ltc4stm1Blam MGI:5517589
hm2
 		Ltc4stm1Blam/Ltc4stm1Blam C.129S7-Ltc4stm1Blam MGI:5316008
hm3
 		Ltc4stm1Blam/Ltc4stm1Blam involves: 129S7/SvEvBrd * BALB/c MGI:3694667
hm4
 		Ltc4stm1Blam/Ltc4stm1Blam involves: 129S7/SvEvBrd * C57BL/6 MGI:3029269


Genotype
MGI:5517589
hm1
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 B6.129S7-Ltc4stm1Blam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis
• however, ear histamine content is normal




Genotype
MGI:5316008
hm2
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 C.129S7-Ltc4stm1Blam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice
• however, dermal infiltration by CD4+ cells and eosinophils is similar to wild-type mice and systemic immune response to EC sensitization with OVA is comparable to wild-type controls

integument
abnormal skin physiology ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin compared to wild-type mice




Genotype
MGI:3694667
hm3
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal type I hypersensitivity reaction ( J:87909 )
• IgE dependent passive cutaneous anaphylaxis significantly reduced
• less swelling




Genotype
MGI:3029269
hm4
Allelic
Composition		 Ltc4stm1Blam/Ltc4stm1Blam
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltc4stm1Blam mutation (2 available); any Ltc4s mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:110309 )
N
• macrophage phagocytosis is normal
respiratory system inflammation ( J:88647 )
• reduced pulmonary inflammation compared to controls 7 days after bleomycin injection
• fewer thickened alveolar septa after bleomycin injection
• decreased extra cellular matrix after bleomycin injection
• decreased clusters of monocytes/macrophage, giant cells, neutrophiles after bleomycin injection
• significantly reduced cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection

cardiovascular system
decreased vascular permeability ( J:87909 )
• reduced vascular permeability as a result of zymosan elicited peritoneal inflammation

respiratory system
respiratory system inflammation ( J:88647 )
• reduced pulmonary inflammation compared to controls 7 days after bleomycin injection
• fewer thickened alveolar septa after bleomycin injection
• decreased extra cellular matrix after bleomycin injection
• decreased clusters of monocytes/macrophage, giant cells, neutrophiles after bleomycin injection
• significantly reduced cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory