All Phenotypes Prkaa1<tm1Sbj> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj	involves: 129	MGI:3842751
hm2	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj	involves: 129S2/SvPas	MGI:7277679
hm3	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj	involves: 129S2/SvPas * C57BL/6J	MGI:3029402
cn4	Prkaa1^tm1Sbj/Prkaa1⁺ Prkaa2^tm1Vio/Prkaa2^tm1Vio	involves: 129S2/SvPas * FVB/N	MGI:3817315
cn5	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Pomc1-cre)1Gsb/0	involves: 129S2/SvPas * FVB/N	MGI:3817316
cx6	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio	involves: 129S2/SvPas	MGI:3817276

Allelic Composition	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1^tm1Sbj mutation (2 available); any Prkaa1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:147215 )

• spleen weight is almost 4-fold greater than controls due to retention of dying erythrocytes

hemolytic anemia ( J:147215 )

• as evident from low red blood cell count, hematocrit, and hemoglobin concentration and an increase in red cell distribution width

• erythrocytes also have higher rates of apoptosis especially under glucose starved conditions

• erythrocytes have a much shorter half-life than controls

low mean erythrocyte cell number ( J:147215 )

• red blood cell count is slightly decreased

decreased hematocrit ( J:147215 )

• hematocrit is decreased

decreased mean corpuscular hemoglobin ( J:147215 )

• is slightly decreased

increased red blood cell distribution width ( J:147215 )

• the red blood cell distribution width is increased in these mice

reticulocytosis ( J:147215 )

• reticulocyte numbers are increased 3-fold in the blood

abnormal erythrocyte osmotic lysis ( J:147215 )

• erythrocytes are significantly more resistant against osmotic lysis while the basal hemolysis at higher osmolarity is slightly but significantly increased

homeostasis/metabolism

abnormal circulating hormone level ( J:147215 )

• plasma erythropoietin levels are greatly increased

immune system

increased spleen weight ( J:147215 )

• spleen weight is almost 4-fold greater than controls due to retention of dying erythrocytes

growth/size/body

increased spleen weight ( J:147215 )

• spleen weight is almost 4-fold greater than controls due to retention of dying erythrocytes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

impaired granulosa cell differentiation ( J:324163 )

• in preantral follicles, granulosa cells are not cuboidal as in control mice and exhibit a non-linear distribution

decreased corpora lutea number ( J:324163 )

• number of corpora lutea per female is reduced by 30%

decreased mature ovarian follicle number ( J:324163 )

• number of healthy pre-ovulatory follicles (with a diameter equal to or greater than 300 um) per ovary is significantly decreased

increased primary ovarian follicle number ( J:324163 )

• number of healthy primary follicles (50-199 um in diameter) is increased by 1.3-fold

increased tertiary ovarian follicle number ( J:324163 )

• number of healthy antral follicles (200-300 um in diameter) is increased by 1.5-fold

increased atretic ovarian follicle number ( J:324163 )

• number of atretic follicles is significantly increased in antral follicles but not in primary follicles or pre-ovulatory follicles, as revealed by visualization of pyknotic bodies

impaired ovarian folliculogenesis ( J:324163 )

• number of anti-Mullerian hormone (AMH)-positive ovarian follicles per ovary is significantly increased (AMH is a marker of large preantral and small antral follicles), whereas the number of pre-ovulatory follicles is significantly decreased

• dysregulation of folliculogenesis is associated with elevated AMH level and excess in androgen production by the ovaries

abnormal secondary ovarian follicle morphology ( J:324163 )

• preantral follicles show decreased expression of beta-catenin (involved in tissue architecture) and altered shape and structure of granulosa cell layers

increased secondary ovarian follicle number ( J:324163 )

• number of large preantral follicles is increased

decreased superovulation rate ( J:324163 )

• following superovulation induction, the number of oocytes recovered is significantly lower than that in superovulated wild-type females

prolonged estrous cycle ( J:324163 )

• estrous cycle length is significantly increased, resulting in a delay between two cycles

• however, estrous phase length is normal

reduced female fertility ( J:324163 )

• 3-month-old females are subfertile

decreased litter size ( J:324163 )

• 3-month-old females mated with wild-type males show a 30% reduction in the number of live pups per litter relative to wild-type females

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:324163 )

• protein expression of enzymes involved in steroid production is significantly increased in whole ovary lysates, consistent with a hyperandrogenic response

abnormal hormone level ( J:324163 )

• anti-Mullerian hormone (AMH) protein levels and steroid levels (pregnenolone, 17alpha-Hydroxyprogesterone, delta4 androstenedione, and testosterone) levels are significantly increased in whole ovary extracts

increased circulating anti-Mullerian hormone level ( J:324163 )

• serum anti-Mullerian hormone (AMH) levels are significantly increased

abnormal testosterone level ( J:324163 )

• testosterone level is significantly increased in whole ovary extracts

• however, blood testosterone level is normal

endocrine/exocrine glands

impaired granulosa cell differentiation ( J:324163 )

• in preantral follicles, granulosa cells are not cuboidal as in control mice and exhibit a non-linear distribution

decreased corpora lutea number ( J:324163 )

• number of corpora lutea per female is reduced by 30%

decreased mature ovarian follicle number ( J:324163 )

• number of healthy pre-ovulatory follicles (with a diameter equal to or greater than 300 um) per ovary is significantly decreased

increased primary ovarian follicle number ( J:324163 )

• number of healthy primary follicles (50-199 um in diameter) is increased by 1.3-fold

increased tertiary ovarian follicle number ( J:324163 )

• number of healthy antral follicles (200-300 um in diameter) is increased by 1.5-fold

increased atretic ovarian follicle number ( J:324163 )

• number of atretic follicles is significantly increased in antral follicles but not in primary follicles or pre-ovulatory follicles, as revealed by visualization of pyknotic bodies

impaired ovarian folliculogenesis ( J:324163 )

• dysregulation of folliculogenesis is associated with elevated AMH level and excess in androgen production by the ovaries

abnormal secondary ovarian follicle morphology ( J:324163 )

• preantral follicles show decreased expression of beta-catenin (involved in tissue architecture) and altered shape and structure of granulosa cell layers

increased secondary ovarian follicle number ( J:324163 )

• number of large preantral follicles is increased

cellular

impaired granulosa cell differentiation ( J:324163 )

• in preantral follicles, granulosa cells are not cuboidal as in control mice and exhibit a non-linear distribution

Allelic Composition	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1^tm1Sbj mutation (2 available); any Prkaa1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle cell glucose uptake ( J:87719 )

• contraction-stimulated glucose uptake is decreased by about 25% in soleus muscle, but not in extensor digitorum longus (EDL) muscle

• however, normal 5-aminoimidazole-4-carboxamide-1-beta-4 ribofuranoside (AICAR)-induced glucose uptake in skeletal muscle

cellular

decreased skeletal muscle cell glucose uptake ( J:87719 )

• contraction-stimulated glucose uptake is decreased by about 25% in soleus muscle, but not in extensor digitorum longus (EDL) muscle

• however, normal 5-aminoimidazole-4-carboxamide-1-beta-4 ribofuranoside (AICAR)-induced glucose uptake in skeletal muscle

Allelic Composition	Prkaa1^tm1Sbj/Prkaa1⁺ Prkaa2^tm1Vio/Prkaa2^tm1Vio
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1^tm1Sbj mutation (2 available); any Prkaa1 mutation (46 available)
Prkaa2^tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:123951 )

• compared to wild-type mice

increased susceptibility to diet-induced obesity ( J:123951 )

• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Pomc1-cre)1Gsb mice

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:123951 )

• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Pomc1-cre)1Gsb mice

Allelic Composition	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Pomc1-cre)1Gsb/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:123951 )

• compared to wild-type mice

Allelic Composition	Prkaa1^tm1Sbj/Prkaa1^tm1Sbj Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1^tm1Sbj mutation (2 available); any Prkaa1 mutation (46 available)
Prkaa2^tm1.1Vio mutation (1 available); any Prkaa2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:141132 )

N	• mouse embryonic fibroblasts exhibit normal differentiation into myofibroblasts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24