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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Piwil2tm1Nkn
targeted mutation 1, Toru Nakano
MGI:3029596
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Piwil2tm1Nkn/Piwil2tm1Nkn involves: 129S2/SvPas * C57BL/6 MGI:3029634
cx2
 		Piwil2tm1Nkn/Piwil2tm1Nkn
Tg(Piwil2)#Hsas/0 		involves: 129S2/SvPas MGI:5469310


Genotype
MGI:3029634
hm1
Allelic
Composition		 Piwil2tm1Nkn/Piwil2tm1Nkn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2tm1Nkn mutation (1 available); any Piwil2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:87735 )
N
• female mice were fertile
azoospermia ( J:87735 )
• absence of spermatozoa in adult epididymides
• spermatogonia, spermatocytes, and spermatids were detected in adult testes
arrest of male meiosis ( J:87735 )
• block at early prophase (zygotene to early pachytene) of meioisis I
increased male germ cell apoptosis ( J:87735 )
• increased apoptosis following arrest of meiosis
decreased testis weight ( J:87735 )
• normal testes size from development through 2 weeks of age, suggesting normal spermatogonia
• testes ceased to grow and were one-fifth the weight of those of wild-type by 10 weeks of age

endocrine/exocrine glands
decreased testis weight ( J:87735 )
• normal testes size from development through 2 weeks of age, suggesting normal spermatogonia
• testes ceased to grow and were one-fifth the weight of those of wild-type by 10 weeks of age

cellular
azoospermia ( J:87735 )
• absence of spermatozoa in adult epididymides
• spermatogonia, spermatocytes, and spermatids were detected in adult testes
arrest of male meiosis ( J:87735 )
• block at early prophase (zygotene to early pachytene) of meioisis I
increased male germ cell apoptosis ( J:87735 )
• increased apoptosis following arrest of meiosis




Genotype
MGI:5469310
cx2
Allelic
Composition		 Piwil2tm1Nkn/Piwil2tm1Nkn
Tg(Piwil2)#Hsas/0
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2tm1Nkn mutation (1 available); any Piwil2 mutation (54 available)
Tg(Piwil2)#Hsas mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:192826 )
N
• male mice exhibit normal spermatogenesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory